Title:Molecular Mechanisms of Polyphenols in Management of Skin Aging
Volume: 17
Issue: 3
Author(s): Deepti Dwevedi*Ankur Srivastava
Affiliation:
- Department of Pharmacy, Dr. Ram Manohar Lohia Avadh University, Faizabad, Ayodhya District, Uttar Pardesh,
India
Keywords:
Polyphenol, skin aging, UV radiation, antioxidant activity, collagen degradation, extracellular matrix.
Abstract: The natural process of skin aging is influenced by a variety of factors, including oxidative
stress, inflammation, collagen degradation, and UV radiation exposure. The potential of polyphenols
in controlling skin aging has been the subject of much investigation throughout the
years. Due to their complex molecular pathways, polyphenols, a broad class of bioactive substances
present in large quantities in plants, have emerged as attractive candidates for skin anti-aging
therapies. This review aims to provide a comprehensive overview of the molecular mechanisms
through which polyphenols exert their anti-aging effects on the skin. Various chemical
mechanisms contribute to reducing skin aging signs and maintaining a vibrant appearance. These
mechanisms include UV protection, moisturization, hydration, stimulation of collagen synthesis,
antioxidant activity, and anti-inflammatory actions. These mechanisms work together to reduce
signs of aging and keep the skin looking youthful. Polyphenols, with their antioxidant properties,
are particularly noteworthy. They can neutralize free radicals, lessening oxidative stress that might
otherwise cause collagen breakdown and DNA damage. The anti-inflammatory effects of polyphenols
are explored, focusing on their ability to suppress pro-inflammatory cytokines and enzymes,
thereby alleviating inflammation and its detrimental effects on the skin. Understanding these
mechanisms can guide future research and development, leading to the development of innovative
polyphenol-based strategies for maintaining healthy skin.
