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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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Mini-Review Article

Ramifications of m6A Modification on ncRNAs in Cancer

Author(s): Rashid Mehmood*

Volume 25, Issue 3, 2024

Published on: 09 April, 2024

Page: [158 - 170] Pages: 13

DOI: 10.2174/0113892029296712240405053201

open access plus

Abstract

N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing, export, translation, and stability of the modified mRNA. Recent evidence suggests that various classes of noncoding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long con-coding RNAs (lncRNAs), are also targeted by this modification. Depending on the ncRNA species, m6A may affect the processing, stability, or localization of these molecules. The m6Amodified ncRNAs are implicated in a number of diseases, including cancer. In this review, the author summarizes the role of m6A modification in the regulation and functions of ncRNAs in tumor development. Moreover, the potential applications in cancer prognosis and therapeutics are discussed.

Keywords: ncRNAs, m6A modification, cancer, RNA metabolism, long con-coding RNAs, microRNAs.

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