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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry

Author(s): Nursyuhada Azzman, Sirajudheen Anwar, Wan Ahmad Syazani Mohamed and Nafees Ahemad*

Volume 24, Issue 13, 2024

Published on: 08 April, 2024

Page: [1134 - 1157] Pages: 24

DOI: 10.2174/0115680266300736240403075307

Price: $65

Abstract

Quinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, microtubules, protein kinases, phosphoinositide 3-kinases (PI3K) and histone deacetylase (HDAC). Hybrids of quinolone with curcumin or chalcone, 2-phenylpyrroloquinolin-4-one and 4-quinolone derivatives have demonstrated strong potency against cancer cell lines. Additionally, quinolones have been explored as inhibitors of protein kinases, including EGFR and VEGFR. Therefore, this review aims to consolidate the medicinal chemistry of quinolone derivatives in the pipeline and discuss their similarities in terms of their pharmacokinetic profiles and potential target sites to provide an understanding of the structural requirements of anticancer quinolones.

Keywords: Quinolone, Anticancer, Topoisomerase, Hybrid, Tyrosine kinase, Histone deacetylase, Small molecules.

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