Abstract
Retinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of action of caveolin-1 might be related to the regulation of relevant signal pathways and looked ahead the application prospects of modulating caveolin- 1 in retinal neovascularization diseases.
Keywords: Neovascularization, caveolin, retina, retinal neovascular diseases, plasma membrane, caveolin.
Current Drug Targets
Title:The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Volume: 25 Issue: 7
Author(s): Rui Zhang and Yalong Dang*
Affiliation:
- Department of Ophthalmology, Sanmenxia Eye Hospital/Sanmenxia Central Hospital Affiliated to Henan University of Science and Technology, Sanmenxia, 472000, China
- Henan International Joint Laboratory of Outflow Engineering, Sanmenxia Central Hospital, School of Medicine, Henan University of Science and Technology, Sanmenxia, 47200, China
Keywords: Neovascularization, caveolin, retina, retinal neovascular diseases, plasma membrane, caveolin.
Abstract: Retinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of action of caveolin-1 might be related to the regulation of relevant signal pathways and looked ahead the application prospects of modulating caveolin- 1 in retinal neovascularization diseases.
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Cite this article as:
Zhang Rui and Dang Yalong*, The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization, Current Drug Targets 2024; 25 (7) . https://dx.doi.org/10.2174/0113894501310201240403065930
DOI https://dx.doi.org/10.2174/0113894501310201240403065930 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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