Title:COVID-19 Beyond the Lungs: Neuropsychiatric Symptoms and EEG Correlations
Volume: 21
Issue: 1
Author(s): Anna Gaia Attardi, Graziana Ceraolo, Federica Galletta, Maria Grazia Maimone and Greta Amore*
Affiliation:
- Unit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age,
"Gaetano Barresi" University of Messina, 98124, Messina, Italy
Keywords:
EEG correlates, electroencephalography, MIS-C, neuropsychiatric manifestations, pediatric population, post- COVID-19 syndrome, SARS-CoV-2.
Abstract: COVID-19, previously considered a mere respiratory illness affecting predominantly
the adult age, is today acknowledged as the cause of a wide spectrum of multisystemic signs and
symptoms, ranging from mild to severe degrees, including neurological manifestations. Even if
less frequently than adults, pediatric patients may also develop severe COVID-19 and present
with peculiar clinical pictures, including multi-system inflammatory syndrome (MIS-C) and neuropsychiatric
manifestations. Mounting evidence is available on the potential pathogenic mechanisms
underpinning the nervous system involvement and on the Post-COVID19 sequelae. However,
little is known about EEG changes that may come along with them, particularly in the pediatric
age. Herein, we briefly overview the neuropsychiatric COVID-19-related features in pediatric
patients and the reported potential EEG correlates. Further research may help unravel new insights
and provide new biomarkers regarding diagnosis, prognosis, and treatment options for post-
COVID-19 neuro-cognitive disorders.
