Title:Antimicrobial Potential of Natural Compounds of Zingiberaceae Plants and their Synthetic Analogues: A Scoping Review of In vitro and In silico Approaches
Volume: 24
Issue: 13
Author(s): Kok-Hou Yit and Zamirah Zainal-Abidin*
Affiliation:
- Department of Craniofacial Diagnostics & Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia,
50300, Kuala Lumpur, Malaysia
Keywords:
Antimicrobial, Bioactive compounds, Synthetic derivatives, Zingiberaceae, In vitro, In silico.
Abstract:
Aims: There has been increased scientific interest in bioactive compounds and their synthetic
derivatives to promote the development of antimicrobial agents that could be used sustainably
and overcome antibiotic resistance.
Methods: We conducted this scoping review to collect evidence related to the antimicrobial potential
of diverse natural compounds from Zingiberaceae plants and their synthetic derivatives. We
followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension
for Scoping Reviews guidelines. The literature search was conducted using PubMed, Web
of Science and Scopus electronic databases for relevant studies published from 2012 to 2023. A total
of 28 scientific studies fulfilled the inclusion criteria. The authors of these studies implemented
in vitro and in silico methods to examine the antimicrobial potency and underlying mechanisms of
the investigated compounds.
Result: The evidence elucidates the antimicrobial activity of natural secondary metabolites from
Zingiberaceae species and their synthetic derivatives against a broad panel of gram-positive and
gram-negative bacteria, fungi and viruses.
Conclusion: To date, researchers have proposed the application of bioactive compounds derived
from Zingiberaceae plants and their synthetic analogues as antimicrobial agents. Nevertheless,
more investigations are required to ascertain their efficacy and to broaden their commercial applicability.
