Review Article

Role of miRNAs in Brain Development

Author(s): Himanshu Sharma, Monika Kaushik, Priyanka Goswami, Sanakattula Sreevani, Ananya Chakraborty, Sumel Ashique* and Radheshyam Pal

Volume 13, Issue 2, 2024

Published on: 02 April, 2024

Page: [96 - 109] Pages: 14

DOI: 10.2174/0122115366287127240322054519

Price: $65

Abstract

Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a conse-quence in neutralizing gene activity after transcription. The nervous system is a massively ex-pressed organ, and an expanding body of research reveals the vital functions that miRNAs play in the brain's growth and neural activity. The significant benefit of miRNAs on the development of the central nervous system is currently shown through new scientific methods that concentrate on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes on neural progenitors, like differentiation, proliferation, and destiny determination. Current re-search discoveries that emphasize the significance of miRNAs in the complex process of brain development are included in this book. The miRNA pathway plays a major role in brain devel-opment, its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of this. We also discussed how these discoveries may affect our comprehension of the fundamental processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs pro-vide for treating various human illnesses.

Keywords: miRNA, biogenesis, miR-17-92, miR-9, bio-markers, brain physiology, brain development, neurodegeneration.


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