Title:Role of miRNAs in Brain Development
Volume: 13
Issue: 2
Author(s): Himanshu Sharma, Monika Kaushik, Priyanka Goswami, Sanakattula Sreevani, Ananya Chakraborty, Sumel Ashique*Radheshyam Pal
Affiliation:
- Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India
Keywords:
miRNA, biogenesis, miR-17-92, miR-9, bio-markers, brain physiology, brain development, neurodegeneration.
Abstract: Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a consequence
in neutralizing gene activity after transcription. The nervous system is a massively expressed
organ, and an expanding body of research reveals the vital functions that miRNAs play
in the brain's growth and neural activity. The significant benefit of miRNAs on the development
of the central nervous system is currently shown through new scientific methods that concentrate
on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and
DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes
on neural progenitors, like differentiation, proliferation, and destiny determination. Current research
discoveries that emphasize the significance of miRNAs in the complex process of brain
development are included in this book. The miRNA pathway plays a major role in brain development,
its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene
regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of
this. We also discussed how these discoveries may affect our comprehension of the fundamental
processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs provide
for treating various human illnesses.
