Title:The Renoprotective and Anti-Inflammatory Effects of Human Urine-Derived Stem Cells on Acute Kidney Injury Animals
Volume: 20
Issue: 2
Author(s): Yuanyuan Kuang, Chenyu Fan, Xiaojun Long, Jiajia Zheng, Yunsi Zeng, Yuhui Wei, Jiasheng Zhang, Shuangjin Yu, Tong Chen, Hehuan Ruan, Yi Wang, Ning Na*, Yiming Zhou*Jiang Qiu*
Affiliation:
- Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China
- Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China
- Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China
Keywords:
Acute kidney injury, urine-derived stem cell, cell therapy, anti-inflammation, proximal tubule cell, mesenchymal stem cell.
Abstract:
Background : Acute Kidney Injury (AKI) is defined as a sudden loss of kidney function,
which is often caused by drugs, toxins, and infections. The large spectrum of AKI implies diverse
pathophysiological mechanisms. In many cases, AKI can be lethal, and kidney replacement
therapy is frequently needed. However, current treatments are not satisfying. Developing novel
therapies for AKI is essential. Adult stem cells possess regenerative ability and play an important
role in medical research and disease treatment.
Methods: In this study, we isolated and characterized a distinct human urine-derived stem cell,
which expressed both proximal tubular cell and mesenchymal stem cell genes as well as certain
unique genes.
Results: It was found that these cells exhibited robust protective effects on tubular cells and anti-
inflammatory effects on macrophages in vitro. In an ischemia-reperfusion-induced acute kidney
injury NOD-SCID mouse model, transplantation of USCs significantly protected the kidney morphology
and functions in vivo.
Conclusion: In summary, our results highlighted the effectiveness of USCs in protecting from
PTC injury and impeding macrophage polarization, as well as the secretion of pro-inflammatory
interleukins, suggesting the potential of USCs as a novel cell therapy in AKI.
