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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Editorial

Genomics in Diabetic Kidney Disease: A 2024 Update

Author(s): Stefanos Roumeliotis*, Maria Divani, Eleni Stamellou and Vassilios Liakopoulos

Volume 25, Issue 3, 2024

Published on: 02 April, 2024

Page: [153 - 157] Pages: 5

DOI: 10.2174/0113892029300247240325080421

Open Access Journals Promotions 2
Abstract

Diabetic Kidney Disease (DKD) remains the leading cause of Chronic and End Stage Kidney Disease (ESKD) worldwide, with an increasing epidemiological burden. However, still, the disease awareness remains low, early diagnosis is difficult, and therapeutic management is ineffective. These might be attributed to the fact that DKD is a highly heterogeneous disease, with disparities and variability in clinical presentation and progression patterns. Besides environmental risk factors, genetic studies have emerged as a novel and promising tool in the field of DKD. Three decades ago, family studies first reported that inherited genetic factors might confer significant risk to DKD development and progression. During the past decade, genome-wide association studies (GWASs) screening the whole genome in large and multi-ethnic population-based cohorts identified genetic risk variants associated with traits defining DKD in both type 1 and 2 diabetes. Herein, we aim to summarize the existing data regarding the progress in the field of genomics in DKD, present how the revolution of GWAS expanded our understanding of pathophysiologic disease mechanisms and finally, suggest potential future directions.

Keywords: Chronic kidney disease, diabetic kidney disease, end-stage kidney disease, genomics, GWAS, single nucleotide polymorphisms.

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