Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis

Title:Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis

Volume: 20 Issue: 5

Author(s): Leandro Tolfo Franzoni*, Stephanie Bastos da Motta, Gabriel Carvalho, Rochelle Rocha Costa, Mabel Marciela Ahner, Marco Aurélio Lumertz Saffi, Alexandre Araújo Pereira, Adamastor Humberto Pereira, Anderson Donelli da Silveira and Ricardo Stein

Affiliation:

• Programa de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul – Porto Alegre, Brazil
• Grupo de Pesquisa em Cardiologia do Exercício do Hospital de Clínicas de Porto Alegre - Porto Alegre, Brazil

Keywords: Transplant, inflammation, biomarkers, aerobic modality, interleukin-6, heart transplant.

Abstract:

Background: Physical exercise (PE) may improve plasma concentration of interleukin- 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and adiponectin (adpN) in heart transplant (HT) patients. However, no consistent data is available on this population.

Aim: Thus, we aimed to conduct a systematic review and meta-analysis on the effects of PE over these pro- and anti-inflammatory biomarkers in HT patients.

Methods: Following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, we conducted a systematic literature search in the PubMed, Cochrane, and Scopus databases. Outcomes included IL-6, TNF-alpha, and adpN. Effect size (ES) was calculated using the standardized mean difference with a 95% confidence interval (CI).

Results: The PE group (aerobic modality) was associated with reduced IL-6 compared to the control group (ES: −0.53; 95% CI: −0.99 to −0.06 pg/mL; P = 0.026). However, the PE group did not show a significant effect on TNF-alpha and adpN levels (ES: −0.33; 95% CI: −0.79 to 0.13; P = 0.16 and ES: −0.20; 95% CI: −0.70 to 0.30 pg/mL; P = 0.444, respectively).

Conclusion: PE is associated with IL-6 reductions, although TNF alpha and adpN did not change after this intervention in HT patients. Therefore, PE is an effective intervention to downregulate IL-6 in post-HT patients.

Cite this article as:

Franzoni Tolfo Leandro*, da Motta Bastos Stephanie, Carvalho Gabriel, Costa Rocha Rochelle, Ahner Marciela Mabel, Saffi Aurélio Lumertz Marco, Pereira Araújo Alexandre, Pereira Humberto Adamastor, da Silveira Donelli Anderson and Stein Ricardo, Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis, Current Cardiology Reviews 2024; 20 (5) : e020424228544 . https://dx.doi.org/10.2174/011573403X269909240320061952