Title:Drug Repurposing Using FDA Adverse Event Reporting System (FAERS)
Database
Volume: 25
Issue: 7
关键词:
FAERS, FDA，药物再利用，LINCS，药物重新定位，连接映射，CMAP，药物警戒。
摘要: Drug repurposing is an emerging approach to reassigning existing pre-approved therapies
for new indications. The FDA Adverse Event Reporting System (FAERS) is a large database
of over 28 million adverse event reports submitted by medical providers, patients, and drug manufacturers
and provides extensive drug safety signal data. In this review, four common drug repurposing
strategies using FAERS are described, including inverse signal detection for a single disease,
drug-drug interactions that mitigate a target ADE, identifying drug-ADE pairs with opposing
gene perturbation signatures and identifying drug-drug pairs with congruent gene perturbation signatures.
The purpose of this review is to provide an overview of these different approaches using
existing successful applications in the literature. With the fast expansion of adverse drug event reports,
FAERS-based drug repurposing represents a promising strategy for discovering new uses
for existing therapies.
