Title:Solid CaCO3 Formation in Glioblastoma Multiforme and its Treatment
with Ultra-Nanoparticulated NPt-Bionanocatalysts
Volume: 25
Issue: 3
Author(s): Tessy López-Goerne*, Alfonso Arellano, Francisco J. Padilla-Godínez, Carlos Magaña, Antonela González-Bondani and Rafael Valiente
Affiliation:
- Department of Health Care, Nanotechnology and Nanomedicine Laboratory, Metropolitan Autonomous University, Xochimilco, Mexico City, 04960, Mexico
Keywords:
Bionanocatalyst, Pt/TiO2, NPt, glioblastoma multiforme, CaCO3, catalytic nanomedicine.
Abstract:
Background: Glioblastoma multiforme (GBM), the most prevalent form of central nervous
system (CNS) cancer, stands as a highly aggressive glioma deemed virtually incurable according
to the World Health Organization (WHO) standards, with survival rates typically falling
between 6 to 18 months. Despite concerted efforts, advancements in survival rates have been elusive.
Recent cutting-edge research has unveiled bionanocatalysts with 1% Pt, demonstrating unparalleled
selectivity in cleaving C-C, C-N, and C-O bonds within DNA in malignant cells. The application
of these nanoparticles has yielded promising outcomes.
Objective: The objective of this study is to employ bionanocatalysts for the treatment of Glioblastoma
Multiforme (GBM) in a patient, followed by the evaluation of obtained tissues through electronic
microscopy.
Methods: Bionanocatalysts were synthesized using established protocols. These catalysts were
then surgically implanted into the GBM tissue through stereotaxic procedures. Subsequently, tissue
samples were extracted from the patient and meticulously examined using Scanning Electron
Microscopy (SEM).
Results and Discussion: Detailed examination of biopsies via SEM unveiled a complex network
of small capillaries branching from a central vessel, accompanied by a significant presence of
solid carbonate formations. Remarkably, the patient subjected to this innovative approach exhibited
a three-year extension in survival, highlighting the potential efficacy of bionanocatalysts in
combating GBM and its metastases.
Conclusion: Bionanocatalysts demonstrate promise as a viable treatment option for severe cases
of GBM. Additionally, the identification of solid calcium carbonate formations may serve as a diagnostic
marker not only for GBM but also for other CNS pathologies.
