Title:Formulation and Evaluation of Aprepitant Nanosuspension by Nano Precipitation Techniques
Volume: 14
Author(s): Himansu Bhusan Samal, Lipsa Samal, Annada Kar, Itishree Jogamaya Das, Bishal Sarkar, Arijit Mondal and Suddhasattya Dey*
Affiliation:
- Department of Pharmacy, IQ City Institute of Pharmaceutical Sciences, IQ City Road, Sovapur, Jemua, Durgapur,
West Bengal, India
Keywords:
Aprepitant, bioavailability, nanoprecipitation techniques, nanosuspension, polydispersity, solubility profile.
Abstract: Objective: The majority of new chemical substances generated by the drug development
process are poorly water-soluble or lipophilic. Formulation of a poorly water-soluble substance
is a difficult task for the pharmaceutical industry. It is widely acknowledged that using nanosuspension
in drug administration enhances the drug’s solubility, dissolution, and ultimately bioavailability.
This study aimed to examine the particle sizes of nanosuspensions made by nanoprecipitation
techniques and improve their effectiveness.
Methods: Aprepitant’s nanosuspension has been produced by nanoprecipitation techniques. The
particle size, polydispersity index, along zeta potential of the produced nanosuspensions were measured.
The optimized nanosuspension has been investigated further for solubility, dissolution, surface
morphology, FT-IR, DSC as well as stability studies.
Results: The combination of tween 80 and poloxamer 188 as stabilizer resulted in the preparation
of an optimized nanosuspension (F9) with a particle size of 738 nm, polydispersity index 0.236,
zeta potential -15.1 mV and an improved solubility and dissolution profile compared to pure
drugs. Positive performance improvement was observed in the solubility and dissolution studies.
The crystallinity changed upon nanosizing, as demonstrated by the SEM, FT-IR and DSC analysis.
Conclusion: The nanoprecipitation method was effective in producing a stable Aprepitant nanosuspension
with improved solubility and dissolution rate.
