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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Review Article

Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-based Nanoparticles

Author(s): Md. Moidul Islam and Sarjana Raikwar*

Volume 31, Issue 3, 2024

Published on: 20 March, 2024

Page: [209 - 228] Pages: 20

DOI: 10.2174/0109298665292469240228064739

Price: $65

Abstract

Oral drug delivery is a prevalent and cost-effective method due to its advantages, such as increased drug absorption surface area and improved patient compliance. However, delivering proteins and peptides orally remains a challenge due to their vulnerability to degradation by digestive enzymes, stomach acids, and limited intestinal membrane permeability, resulting in poor bioavailability. The use of nanotechnology has emerged as a promising solution to enhance the bioavailability of these vital therapeutic agents. Polymeric NPs, made from natural or synthetic polymers, are commonly used. Natural polysaccharides, such as alginate, chitosan, dextran, starch, pectin, etc., have gained preference due to their biodegradability, biocompatibility, and versatility in encapsulating various drug types. Their hydrophobic-hydrophilic properties can be tailored to suit different drug molecules.

Keywords: Polysaccharide-based nanoparticles, proteins, oral bioavailability, drug delivery, peptides, nanoparticles.

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