Abstract
Aims: The study aimed to develop pharmaceutical nutraceutical capsules containing extracts from sunflower seeds to treat anemia and associated diseases. Sunflower seed extract (SFSE) was obtained from Helianthus annuus L, and the phytochemicals, antioxidant vitamins and mineral compositions were evaluated.
Methods: Pharmaceutics evaluations were analyzed using the dried extracts to determine their flowability. The extracts were further formulated into capsule dosage forms and evaluated. The phytochemical screening of sunflower seed extract and powdered crude indicated the presence of tannin, flavonoid, phenol, saponins, phytate, oxalate, alkaloids and steroids. The quantitative phytochemical composition of sunflower seed extract revealed a high alkaloid content of 11.80 ± 0.02%, steroid composition of 2.80 ± 0.01% and a phenolic compound of 0.02 ± 0.00%. SFSE also showed different amounts of antioxidants, vitamins A, C, and E. Vitamin C (1924.20 μg/mg) was significantly the highest (p<0.05), followed by vitamin E (42.01±1.02 μg/mg), and the least was vitamin A (18.01 μg/mg). The micromeritics studies of the dried powdered extract revealed an excellent flow. The extracts were adequately formulated in capsules using hard-shell gelatin capsules in combination with compatible pharmaceutical-grade excipients. The uniformity of capsule weight showed an average weight of 488 mg ± 0.7377% and 492 mg ± 0.3252%.
Results: The data obtained from the extracts' content analysis showed that the extracts and all their constituents were neither affected by formulation procedures nor excipients. Hence, they exhibited an average content of 98 ± 0.07%. Zinc, iron, copper, manganese, and selenium in sunflower seeds could provide antioxidants, which can safely interact with free radicals and terminate the chain reaction, improving health status and the blood's red blood cell composition.
Conclusion: SFSE capsules were stable and could be used to mask the taste and odor of this extract to enhance patient compliance.
Keywords: Anemia, antioxidants, hypoglycemia, Helianthus annuus, iron, nutraceuticals, herbal formulations, sunflower seeds.
Call for Papers in Thematic Issues
Nutraceutical Compounds from Waste Bioresources
This thematic issue explores the potential of converting waste bioresources into valuable nutraceutical compounds. The issue will cover advanced extraction techniques, including supercritical-fluid extraction, pressurized-liquid extraction, and microwave-assisted extraction, which offer efficient methods for recovering valuable compounds like secondary metabolites, minerals, vitamins, and phytochemicals from these waste materials. The focus ...read more
Plant-Based Nutraceuticals: A Sustainable Approach to Healthier Tomorrows
The scope of this thematic issue is to explore the rapidly expanding field of plant-based nutraceuticals, with an emphasis on sustainably sourced botanical ingredients. We kindly invite the submission of review articles, as well as original research and commentaries, that investigate the potentials of various plant-based nutraceuticals in promoting health ...read more
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