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Review Article

抗肥胖药物发现研究:缩短药物发现管道的体外模型

卷 25, 期 6, 2024

发表于: 18 March, 2024

页: [388 - 403] 页: 16

弟呕挨: 10.2174/0113894501289136240312060838

价格: $65

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摘要

肥胖是一个日益严重的全球健康问题，导致各种慢性疾病。尽管有标准的治疗方案，但肥胖的患病率仍在持续上升，这强调了对新药的需求。体外药物发现研究方法为鉴定新的抗肥胖药物提供了一个节省时间和成本的平台。该综述涵盖了使用体外模型的肥胖和药物发现研究的各个方面。除了讨论病因、诊断、预防和治疗外，本文还重点介绍了体外研究的优点和局限性，并详尽地涵盖了基于不同动物和人类的酶和细胞系的模型。与传统的体内动物研究相比，使用酶和细胞系为基础的体外临床前试验为抗肥胖药物的开发提供了几个优势。这些方法快速，经济实惠，并提供高通量筛选。它们还可以提供有关药物靶标相互作用、作用方式和毒性概况的深刻信息。通过揭示导致肥胖的因素，体外测试也为个性化治疗提供了机会。技术将继续发展，导致更精确、更可靠的体外检测的产生，这将在寻找新型抗肥胖药物方面变得越来越重要。

关键词: 胰脂肪酶抑制，肥胖和超重，BMI，细胞系，临床前试验，体重管理，抗肥胖药物。

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