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Current Analytical Chemistry

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ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

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Review Article

Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations

Author(s): Aleksandra Radoičić, Sandra Šegan*, Aleksandra Dramićanin and Dušanka Milojković-Opsenica

Volume 20, Issue 5, 2024

Published on: 08 March, 2024

Page: [295 - 317] Pages: 23

DOI: 10.2174/0115734110290557240305045032

Price: $65

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Abstract

For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules, during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid Chromatography (HILIC) has experienced vast expansion. It is based on the use of a highly hydrophilic stationary phase along with an aqueous mobile phase with high organic modifier content. In this review, the characteristics of stationary and mobile phases used in HILIC are described, and corresponding separation mechanisms are discussed. An overview of recently published papers dealing with the application of HILIC in analyzing pharmaceuticals in biological and non-biological samples is provided. Besides, the application of HILIC systems in the determination of the physicochemical properties of compounds is described.

Keywords: Hydrophilic interaction liquid chromatography, pharmaceutical application, polar compounds, polar stationary phase, hydrophilic partitioning, hydrogen bonding, electrostatic interactions.

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