![conference banner](/images/conference-banner.jpeg)
Abstract
Selenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, and immune function enhancement, are improved compared with traditional organic and inorganic selenium compounds, conferring greater potential for application in biomedicine. Therefore, this review evaluates the advancements in various synthesis methodologies for polysaccharide selenium nanoparticles (Se NPs) and their biological activities. It aims to provide a comprehensive theoretical basis and research directions for the future development of highly efficient, minimally toxic, and biocompatible polysaccharide-Se NPs and the application of polysaccharide-Se NPs in biomedicine.
Keywords: Selenium nanoparticles, polysaccharides, synthesis methods, anti-tumor, anti-inflammatory, antibacterial.
[http://dx.doi.org/10.1016/S0140-6736(11)61452-9] [PMID: 22381456]
[http://dx.doi.org/10.1016/j.ecoenv.2020.111772] [PMID: 33316726]
[http://dx.doi.org/10.3390/ijms222111708] [PMID: 34769138]
[http://dx.doi.org/10.22034/ecc.2023.381964.1594]
[http://dx.doi.org/10.3390/nu10091203] [PMID: 30200430]
[http://dx.doi.org/10.3390/nu14122433] [PMID: 35745163]
[http://dx.doi.org/10.3109/02713683.2011.639123] [PMID: 22273266]
[http://dx.doi.org/10.1038/s41574-019-0311-6] [PMID: 32001830]
[http://dx.doi.org/10.1074/jbc.REV120.008207] [PMID: 33219130]
[http://dx.doi.org/10.1007/s13311-021-01111-9] [PMID: 34498224]
[http://dx.doi.org/10.1093/ajcn/nqaa245] [PMID: 33053149]
[http://dx.doi.org/10.1007/s40520-018-1086-7] [PMID: 30511318]
[http://dx.doi.org/10.1016/j.ejmech.2020.112673] [PMID: 32810750]
[http://dx.doi.org/10.3390/ijms23105509] [PMID: 35628320]
[http://dx.doi.org/10.3390/ijms20215318] [PMID: 31731474]
[http://dx.doi.org/10.3892/ijmm.2021.4986] [PMID: 34165159]
[http://dx.doi.org/10.3390/antiox9010080] [PMID: 31963404]
[http://dx.doi.org/10.1016/j.redox.2022.102346] [PMID: 35636018]
[http://dx.doi.org/10.3390/nu10101466] [PMID: 30304813]
[http://dx.doi.org/10.1001/archinternmed.2009.495] [PMID: 20142570]
[http://dx.doi.org/10.1007/s12263-011-0246-6] [PMID: 21898179]
[PMID: 17193742]
[PMID: 17127727]
[http://dx.doi.org/10.1016/j.aca.2013.09.054] [PMID: 24267061]
[http://dx.doi.org/10.1007/s00604-001-0899-8]
[http://dx.doi.org/10.1016/j.saa.2020.118946] [PMID: 32979808]
[http://dx.doi.org/10.1016/0891-5849(94)90007-8] [PMID: 7959166]
[http://dx.doi.org/10.1016/j.scitotenv.2008.06.024] [PMID: 18657851]
[http://dx.doi.org/10.1080/10408398.2014.934437] [PMID: 25897564]
[http://dx.doi.org/10.3389/fimmu.2019.00133] [PMID: 30774634]
[http://dx.doi.org/10.1039/C7CS00837F] [PMID: 29770813]
[http://dx.doi.org/10.1016/j.copbio.2020.07.006] [PMID: 32795661]
[http://dx.doi.org/10.3390/biomedicines10061374] [PMID: 35740396]
[http://dx.doi.org/10.1002/smll.201900600] [PMID: 30925017]
[http://dx.doi.org/10.3390/ijms23116331] [PMID: 35683010]
[http://dx.doi.org/10.1021/acsomega.9b03172] [PMID: 32095689]
[http://dx.doi.org/10.7150/thno.70830] [PMID: 35664065]
[http://dx.doi.org/10.3390/molecules26185559] [PMID: 34577029]
[http://dx.doi.org/10.2147/IJN.S295053] [PMID: 33469285]
[http://dx.doi.org/10.3390/ijms22030989] [PMID: 33498184]
[http://dx.doi.org/10.1007/s11164-021-04424-8]
[http://dx.doi.org/10.1111/lam.13667] [PMID: 35138666]
[http://dx.doi.org/10.1002/biof.5520150103] [PMID: 11673642]
[http://dx.doi.org/10.1016/j.lfs.2004.02.004] [PMID: 15120575]
[http://dx.doi.org/10.1016/j.jinorgbio.2007.06.021] [PMID: 17664013]
[http://dx.doi.org/10.1016/S0891-5849(03)00428-3] [PMID: 14583345]
[http://dx.doi.org/10.2147/IJN.S157541] [PMID: 29692609]
[http://dx.doi.org/10.1016/j.nut.2016.05.001] [PMID: 27356860]
[http://dx.doi.org/10.1016/j.envpol.2021.116503] [PMID: 33486255]
[http://dx.doi.org/10.1017/S1466252320000183] [PMID: 33355068]
[http://dx.doi.org/10.1016/j.lfs.2004.08.015] [PMID: 15620574]
[http://dx.doi.org/10.1186/1556-276X-9-589] [PMID: 25426004]
[http://dx.doi.org/10.1093/toxsci/kfm221] [PMID: 17728283]
[http://dx.doi.org/10.1002/adhm.202000273] [PMID: 32537940]
[http://dx.doi.org/10.1016/j.jtemb.2020.126549] [PMID: 32731109]
[http://dx.doi.org/10.1016/j.biopha.2018.12.146] [PMID: 30616079]
[http://dx.doi.org/10.1039/C9NR04424H] [PMID: 31363721]
[http://dx.doi.org/10.1007/s10904-020-01462-4]
[http://dx.doi.org/10.1007/s12011-021-02601-9] [PMID: 33512662]
[http://dx.doi.org/10.22034/ecc.2023.369594.1551]
[http://dx.doi.org/10.1016/j.fct.2021.112332] [PMID: 34118349]
[http://dx.doi.org/10.1016/j.scitotenv.2021.145442] [PMID: 33940727]
[http://dx.doi.org/10.1016/j.ecoenv.2021.112135] [PMID: 33780782]
[http://dx.doi.org/10.1007/s11356-021-14775-9] [PMID: 34302249]
[http://dx.doi.org/10.1155/2017/7478523]
[http://dx.doi.org/10.1016/j.fct.2013.12.004] [PMID: 24315870]
[http://dx.doi.org/10.3390/ani11071916] [PMID: 34203158]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.03.016] [PMID: 28274870]
[http://dx.doi.org/10.1016/j.carbpol.2017.09.063] [PMID: 29111042]
[http://dx.doi.org/10.1080/10408398.2015.1069255] [PMID: 26463231]
[http://dx.doi.org/10.1016/j.carbpol.2017.12.009] [PMID: 29352896]
[http://dx.doi.org/10.1016/j.ejpb.2004.02.016] [PMID: 15296959]
[http://dx.doi.org/10.1016/j.carbpol.2020.116052] [PMID: 32172867]
[http://dx.doi.org/10.2147/IJN.S28278] [PMID: 22359460]
[http://dx.doi.org/10.1016/j.colsurfb.2018.07.003] [PMID: 29986266]
[http://dx.doi.org/10.2147/IJN.S151285] [PMID: 29760550]
[http://dx.doi.org/10.1016/j.fsi.2019.01.042] [PMID: 30703551]
[http://dx.doi.org/10.1186/s12951-017-0252-y] [PMID: 28270147]
[http://dx.doi.org/10.2147/IJN.S370585] [PMID: 35832119]
[http://dx.doi.org/10.1016/j.carbpol.2015.07.065] [PMID: 26428112]
[http://dx.doi.org/10.1016/j.jbiotec.2020.11.004] [PMID: 33157197]
[http://dx.doi.org/10.1016/j.drup.2022.100844] [PMID: 35533630]
[http://dx.doi.org/10.1080/21691401.2017.1373657] [PMID: 28880681]
[http://dx.doi.org/10.1016/j.msec.2018.06.036] [PMID: 30184738]
[http://dx.doi.org/10.1016/j.ijbiomac.2019.11.210] [PMID: 31790741]
[http://dx.doi.org/10.3390/ijms221910808] [PMID: 34639150]
[http://dx.doi.org/10.1166/jbn.2014.1985] [PMID: 25992427]
[http://dx.doi.org/10.1016/j.matlet.2007.11.098]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.03.108] [PMID: 29588203]
[http://dx.doi.org/10.1016/j.ijbiomac.2014.01.011] [PMID: 24418338]
[http://dx.doi.org/10.3390/md20030172] [PMID: 35323471]
[http://dx.doi.org/10.1111/jfbc.13363] [PMID: 32648615]
[http://dx.doi.org/10.1371/journal.pone.0251786] [PMID: 34003829]
[http://dx.doi.org/10.1016/j.colsurfb.2008.07.010] [PMID: 18805679]
[http://dx.doi.org/10.1038/srep18629] [PMID: 26686000]
[http://dx.doi.org/10.1016/j.ijbiomac.2021.09.087] [PMID: 34547315]
[http://dx.doi.org/10.1016/j.ijbiomac.2021.03.018] [PMID: 33676981]
[http://dx.doi.org/10.1111/1750-3841.15605] [PMID: 33559173]
[http://dx.doi.org/10.1208/s12249-021-02141-4] [PMID: 34931279]
[http://dx.doi.org/10.1007/s00253-016-7300-7] [PMID: 26801915]
[http://dx.doi.org/10.1016/j.carbpol.2018.04.110] [PMID: 29805014]
[http://dx.doi.org/10.1590/S1517-83822010000200028] [PMID: 24031517]
[http://dx.doi.org/10.1007/s00203-020-02042-3] [PMID: 32968818]
[http://dx.doi.org/10.1002/jsfa.10656] [PMID: 32643806]
[http://dx.doi.org/10.1007/s00449-021-02515-9] [PMID: 33595725]
[http://dx.doi.org/10.1016/j.cis.2020.102166] [PMID: 32387755]
[http://dx.doi.org/10.1155/2019/6871785]
[http://dx.doi.org/10.1016/j.ultsonch.2017.12.022] [PMID: 29429736]
[http://dx.doi.org/10.1021/acs.langmuir.1c02056] [PMID: 34637312]
[http://dx.doi.org/10.1111/1750-3841.16289] [PMID: 35988116]
[http://dx.doi.org/10.3389/fmicb.2019.01632] [PMID: 31402902]
[http://dx.doi.org/10.1016/j.fct.2014.03.003] [PMID: 24626144]
[http://dx.doi.org/10.1016/j.ijbiomac.2019.07.031] [PMID: 31284007]
[http://dx.doi.org/10.1021/acs.jafc.9b00193] [PMID: 30785270]
[http://dx.doi.org/10.1016/j.ijbiomac.2021.10.189] [PMID: 34728301]
[http://dx.doi.org/10.2147/IJN.S29341] [PMID: 22619522]
[http://dx.doi.org/10.2217/nnm-2017-0024] [PMID: 28440710]
[http://dx.doi.org/10.1002/adhm.202100598] [PMID: 34121366]
[http://dx.doi.org/10.1007/s00253-012-4359-7] [PMID: 22945264]
[http://dx.doi.org/10.1016/j.nano.2015.01.009] [PMID: 25680543]
[http://dx.doi.org/10.1016/j.carbpol.2017.12.029] [PMID: 29352947]
[http://dx.doi.org/10.1016/j.ejpb.2018.06.030] [PMID: 29969665]
[http://dx.doi.org/10.1007/s11427-018-9438-y] [PMID: 31054052]
[http://dx.doi.org/10.2147/IJN.S157519] [PMID: 29588583]
[http://dx.doi.org/10.1021/am5031962] [PMID: 25073123]
[http://dx.doi.org/10.1111/jcmm.13897] [PMID: 30472806]
[http://dx.doi.org/10.7150/thno.46467] [PMID: 32802180]
[http://dx.doi.org/10.3389/fnut.2022.987807] [PMID: 36082027]
[http://dx.doi.org/10.1016/j.cell.2011.10.026] [PMID: 22078875]
[http://dx.doi.org/10.1002/cncr.31335] [PMID: 29671878]
[http://dx.doi.org/10.2217/nnm-2018-0397] [PMID: 31355710]
[http://dx.doi.org/10.1039/C9TB01197H] [PMID: 31593205]
[http://dx.doi.org/10.1016/j.jtemb.2022.127006]
[http://dx.doi.org/10.1016/j.cej.2019.122540]
[http://dx.doi.org/10.1016/j.carbpol.2017.11.068] [PMID: 29254044]
[http://dx.doi.org/10.3390/molecules27217290] [PMID: 36364115]
[http://dx.doi.org/10.1038/nature07201] [PMID: 18650913]
[http://dx.doi.org/10.1016/j.cell.2010.02.029] [PMID: 20303877]
[http://dx.doi.org/10.1016/j.ijbiomac.2019.12.061] [PMID: 31830456]
[http://dx.doi.org/10.1016/j.ijbiomac.2022.03.087] [PMID: 35337913]
[http://dx.doi.org/10.1088/2053-1591/ab6a56]
[http://dx.doi.org/10.1016/j.micpath.2022.105544] [PMID: 35443211]
[http://dx.doi.org/10.1007/s11356-020-07651-5] [PMID: 31925699]
[http://dx.doi.org/10.1016/j.plaphy.2021.08.013] [PMID: 34391200]
[http://dx.doi.org/10.1039/C8FO01958D] [PMID: 30662993]
[http://dx.doi.org/10.3390/antiox11020240] [PMID: 35204123]
[http://dx.doi.org/10.3390/pharmaceutics12010043] [PMID: 31947874]
[http://dx.doi.org/10.1101/cshperspect.a028035] [PMID: 28062563]
[http://dx.doi.org/10.1080/17512433.2017.1324781] [PMID: 28463572]
[http://dx.doi.org/10.1016/j.actbio.2015.06.035] [PMID: 26143603]
[http://dx.doi.org/10.1016/j.ijbiomac.2019.09.098] [PMID: 31593732]
[http://dx.doi.org/10.1007/s12011-020-02395-2] [PMID: 32959339]
[http://dx.doi.org/10.1186/s12951-022-01490-x] [PMID: 35701758]
![Wayfinder Image](/images/wayfinder.jpg)