Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source

Title:Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source

Volume: 20

Author(s): Gandhar Pradhan and Yogesh A. Kulkarni*

Affiliation:

• Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), V.L. Mehta Road, Vile Parle (W), Mumbai 400 056, India

Keywords: Luteolin, Flavonoids, Diabetes, Diabetic Cardiomyopathy, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic EncephalopathLuteolin, Diabetic Encephalopathy

Abstract: Flavonoids have been reported to be vital in treating various chronic disorders. Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a flavonoid present in a variety of plant sources such as celery, green pepper, olive oil, peppermint, thyme, rosemary, oregano, etc. It has been reported to have various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, anti-Alzheimer, antimicrobial, etc. Many scientific studies have been carried out on luteolin for its possible effects on diabetes and its associated complications. The present review focuses on the role of luteolin in diabetes mellitus and the associated complications. The antidiabetic impact of luteolin is linked with the increased expression of PPARγ and GLUT. Various in vitro and in vivo studies have been performed to explore the effects of luteolin on diabetic complications, and it has shown a significant impact in the management of the same.

Cite this article as:

Pradhan Gandhar and Kulkarni A. Yogesh*, Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source, Current Diabetes Reviews 2024; 20 () : e290224227537 . https://dx.doi.org/10.2174/0115733998285798240217084632