Title:Advances in Nanoparticulate Therapeutics for Acute Lung Injury: Addressing Unmet Clinical Needs through Targeted Therapy and Controlled Delivery of Drug
Volume: 15
Issue: 2
Author(s): Piyushkumar Sadhu*, Mamta Kumari, Hemraj Singh Rajput, Vipul P. Patel, Falguni Rathod, Nirmal Shah and Avinash Kumar Seth
Affiliation:
- Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India
Keywords:
Acute lung injury, acute respiratory distress syndrome, nanotechnology, targeted drug delivery, gold nanoparticles, polymeric nanoparticles.
Abstract: Background: Acute lung injury (ALI) is a life-threatening condition characterized by
severe invasion of inflammatory cells, lung edema, and the development of intestinal fibrosis. The
activation of proinflammatory cytokines like TNF-α, IL-6, and others results in the development
of several risk factors for ALI. It has been observed that no viable therapies for lung injuries exist.
Therefore, there is a significant need for healthcare requirements. However, few effective nonpharmacological
and pharmacological treatments are available, which may have assisted doctors
in reducing the likelihood of illness development. Still, not much progress has been made in illness
management.
Objectives : This review aimed to briefly discuss pharmacological and non-pharmacological approaches
for treating ALI.
Methods: Nowadays, drug delivery and illness diagnosis are the most advanced areas of modern
nanotechnology research, particularly concerning the lungs. So, we focused on various novel approaches,
viz., organic nanoparticles, inorganic nanoparticles, metal nanoparticles, and bio nanoparticles,
that combat ALI and improve lung functions. This review discussed many studies and
the advancement of different nanomaterials as novel drug carriers in the lungs that can influence
the immune system, suppressing proinflammatory cytokines and improving lung functions.
Result: Another aspect of studying nanotechnology is the release kinetics of nanoparticles and
safety when administered to a targeted tissue.
Conclusion: The higher uptake of nanomaterials and, thus, the drugs is another advancement in
nanotechnology. Herein, we explored different approaches to improving and curing acute lung injury.
