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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

Association Between Cannabis Use and Subjective Cognitive Decline: Findings from the Behavioral Risk Factor Surveillance System (BRFSS)

Author(s): Zhi Chen and Roger Wong*

Volume 20, Issue 11, 2023

Published on: 23 February, 2024

Page: [802 - 810] Pages: 9

DOI: 10.2174/0115672050301726240219050051

Abstract

Background: Cannabis consumption has rapidly increased in the United States due to more states legalizing non-medical and medical use. There is limited research, however, investigating whether cannabis may be associated with cognitive function, particularly across multiple dimensions of cannabis use.

Objective: The objective of this study was to examine whether cannabis consumption reason, frequency, and method are associated with subjective cognitive decline (SCD).

Methods: Data were obtained from 4,744 U.S. adults aged 45 and older in the 2021 Behavioral Risk Factor Surveillance System (BRFSS). SCD was a self-reported increase in confusion or memory loss in the past year. Odds of SCD by cannabis use reason, frequency, and methods (e.g., smoke, eat, vaporize) were examined using multiple logistic regression after imputing missing data, applying sampling weights, and adjusting for sociodemographic, health, and substance use covariates.

Results: Compared to non-users, non-medical cannabis use was significantly associated with 96% decreased odds of SCD (aOR=0.04, 95% CI=0.01-0.44, p<.01). Medical (aOR=0.46, 95% CI=0.06-3.61, p=.46) and dual medical and non-medical use (aOR=0.30, 95% CI=0.03-2.92, p=.30) were also associated with decreased odds of SCD, although not significant. Cannabis consumption frequency and method were not significantly associated with SCD.

Conclusion: The reason for cannabis use, but not frequency and method, is associated with SCD. Further research is needed to investigate the mechanisms that may contribute to the observed associations between non-medical cannabis use and decreased odds of SCD.

Keywords: Cannabis, cognitive decline, dementia, marijuana, older adult, pot.

« Previous Next »
[1]
Taylor, C.A.; Bouldin, E.D.; McGuire, L.C. Subjective cognitive decline among adults aged ≥45 years — United States, 2015–2016. MMWR Morb. Mortal. Wkly. Rep., 2018, 67(27), 753-757.
[http://dx.doi.org/10.15585/mmwr.mm6727a1] [PMID: 30001562]
[2]
Centers for Disease Control and Prevention. Subjective cognitive decline — A public health issue. Available from: https://www.cdc.gov/aging/data/subjective-cognitive-decline-brief.html (Accessed on: July 30, 2019).
[3]
Mitchell, A.J.; Beaumont, H.; Ferguson, D.; Yadegarfar, M.; Stubbs, B. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: Meta-analysis. Acta Psychiatr. Scand., 2014, 130(6), 439-451.
[http://dx.doi.org/10.1111/acps.12336] [PMID: 25219393]
[4]
Pike, K.E.; Cavuoto, M.G.; Li, L.; Wright, B.J.; Kinsella, G.J. Subjective cognitive decline: Level of risk for future dementia and mild cognitive impairment, a meta-analysis of longitudinal studies. Neuropsychol. Rev., 2022, 32(4), 703-735.
[http://dx.doi.org/10.1007/s11065-021-09522-3] [PMID: 34748154]
[5]
National Conference of State Legislatures. State medical cannabis laws. Available from: https://www.ncsl.org/health/state-medical-cannabis-laws (Accessed on: June 22, 2023).
[6]
McKetin, R.; Parasu, P.; Cherbuin, N.; Eramudugolla, R.; Anstey, K.J. A longitudinal examination of the relationship between cannabis use and cognitive function in mid-life adults. Drug Alcohol Depend., 2016, 169, 134-140.
[http://dx.doi.org/10.1016/j.drugalcdep.2016.10.022] [PMID: 27810656]
[7]
Kurtzman, E.T.; Dowling, N.M.; Beebe, S.L. Marijuana use and older adults’ self-reported difficulty concentrating, remembering, or making decisions. J. Stud. Alcohol Drugs, 2022, 83(6), 893-900.
[http://dx.doi.org/10.15288/jsad.21-00318] [PMID: 36484587]
[8]
Wu, L.T.; Blazer, D.G. Illicit and nonmedical drug use among older adults: A review. J. Aging Health, 2011, 23(3), 481-504.
[http://dx.doi.org/10.1177/0898264310386224] [PMID: 21084724]
[9]
Cohen, K.; Weizman, A.; Weinstein, A. Positive and negative effects of cannabis and cannabinoids on health. Clin. Pharmacol. Ther., 2019, 105(5), 1139-1147.
[http://dx.doi.org/10.1002/cpt.1381] [PMID: 30703255]
[10]
Mulhauser, K; Hampstead, BM; Coughlin, LN; Ilgen, MA The association between cannabis use and subjective memory complaints in older adults in the United States. J Int Neuropsychol Soc., 2023, 29(9), 870-877.
[http://dx.doi.org/10.1017/S1355617723000061]
[11]
Lichenstein, S.D. THC, CBD, and anxiety: A review of recent findings on the anxiolytic and anxiogenic effects of cannabis’ primary cannabinoids. Curr. Addict. Rep., 2022, 9(4), 473-485.
[http://dx.doi.org/10.1007/s40429-022-00450-7] [PMID: 38106452]
[12]
Scott, E.P.; Brennan, E.; Benitez, A. A systematic review of the neurocognitive effects of cannabis use in older adults. Curr. Addict. Rep., 2019, 6(4), 443-455.
[http://dx.doi.org/10.1007/s40429-019-00285-9] [PMID: 32477850]
[13]
Olivari, B.S.; Baumgart, M.; Taylor, C.A.; McGuire, L.C. Population measures of subjective cognitive decline: A means of advancing public health policy to address cognitive health. Alzheimers Dement., 2021, 7(1), e12142.
[http://dx.doi.org/10.1002/trc2.12142] [PMID: 33681450]
[14]
Velayudhan, L.; McGoohan, K.L.; Bhattacharyya, S. Evaluation of THC-related neuropsychiatric symptoms among adults aged 50 years and older. JAMA Netw. Open, 2021, 4(2), e2035913.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.35913] [PMID: 33528550]
[15]
Sarne, Y.; Toledano, R.; Rachmany, L.; Sasson, E.; Doron, R. Reversal of age-related cognitive impairments in mice by an extremely low dose of tetrahydrocannabinol. Neurobiol. Aging, 2018, 61, 177-186.
[http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.025] [PMID: 29107185]
[16]
Wong, R.; Lovier, M.A. Sleep disturbances and dementia risk in older adults: Findings from 10 years of national U.S. prospective data. Am. J. Prev. Med., 2023, 64(6), 781-787.
[http://dx.doi.org/10.1016/j.amepre.2023.01.008] [PMID: 36707315]
[17]
Babson, K.A.; Sottile, J.; Morabito, D. Cannabis, cannabinoids, and sleep: A review of the literature. Curr. Psychiatry Rep., 2017, 19(4), 23.
[http://dx.doi.org/10.1007/s11920-017-0775-9] [PMID: 28349316]
[18]
Vaillancourt, R.; Gallagher, S.; Cameron, J.D.; Dhalla, R. Cannabis use in patients with insomnia and sleep disorders: Retrospective chart review. Can. Pharm. J., 2022, 155(3), 175-180.
[http://dx.doi.org/10.1177/17151635221089617] [PMID: 35519083]
[19]
Kuhathasan, N.; Dufort, A.; MacKillop, J.; Gottschalk, R.; Minuzzi, L.; Frey, B.N. The use of cannabinoids for sleep: A critical review on clinical trials. Exp. Clin. Psychopharmacol., 2019, 27(4), 383-401.
[http://dx.doi.org/10.1037/pha0000285] [PMID: 31120284]
[20]
Korten, N.C.M.; Comijs, H.C.; Penninx, B.W.J.H.; Deeg, D.J.H. Perceived stress and cognitive function in older adults: Which aspect of perceived stress is important? Int. J. Geriatr. Psychiatry, 2017, 32(4), 439-445.
[http://dx.doi.org/10.1002/gps.4486] [PMID: 27059116]
[21]
What are marijuana’s effects? Available from: https://nida.nih.gov/publications/research-reports/marijuana/what-are-marijuana-effects (Accessed on: September 13, 2023).
[22]
Broyd, S.J.; van Hell, H.H.; Beale, C.; Yücel, M.; Solowij, N. Acute and chronic effects of cannabinoids on human cognition—A systematic review. Biol. Psychiatry, 2016, 79(7), 557-567.
[http://dx.doi.org/10.1016/j.biopsych.2015.12.002] [PMID: 26858214]
[23]
Sagar, K.A.; Gruber, S.A. Marijuana matters: Reviewing the impact of marijuana on cognition, brain structure and function, & exploring policy implications and barriers to research. Int. Rev. Psychiatry, 2018, 30(3), 251-267.
[http://dx.doi.org/10.1080/09540261.2018.1460334] [PMID: 29966459]
[24]
Pocuca, N.; Walter, T.J.; Minassian, A.; Young, J.W.; Geyer, M.A.; Perry, W. The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review. Arch. Clin. Neuropsychol., 2021, 36(5), 673-685.
[http://dx.doi.org/10.1093/arclin/acaa105] [PMID: 33159510]
[25]
Schauer, G.L.; Njai, R.; Grant-Lenzy, A.M. Modes of marijuana use – Smoking, vaping, eating, and dabbing: Results from the 2016 BRFSS in 12 States. Drug Alcohol Depend., 2020, 209, 107900.
[http://dx.doi.org/10.1016/j.drugalcdep.2020.107900] [PMID: 32061947]
[26]
Jessen, F.; Amariglio, R.E.; Buckley, R.F.; van der Flier, W.M.; Han, Y.; Molinuevo, J.L.; Rabin, L.; Rentz, D.M.; Gomez, R.O.; Saykin, A.J.; Sikkes, S.A.M.; Smart, C.M.; Wolfsgruber, S.; Wagner, M. The characterisation of subjective cognitive decline. Lancet Neurol., 2020, 19(3), 271-278.
[http://dx.doi.org/10.1016/S1474-4422(19)30368-0] [PMID: 31958406]
[27]
Taylor, C.A.; Bouldin, E.D.; Greenlund, K.J.; McGuire, L.C. Comorbid chronic conditions among older adults with subjective cognitive decline, United States, 2015–2017. Innov. Aging., 2020, 4(1), igz045.
[http://dx.doi.org/10.1093/geroni/igz045]
[28]
Porsteinsson, AP; Isaacson, RS; Knox, S; Sabbagh, MN; Rubino, I Diagnosis of early Alzheimer’s disease: Clinical practice in 2021. J Prev Alzheimers Dis, 2021, 8(3), 371-386.
[http://dx.doi.org/10.14283/jpad.2021.23]
[29]
Increase the proportion of adults with subjective cognitive decline who have discussed their symptoms with a provider — DIA‑03 - Healthy People 2030. Available from: https://health.gov/healthypeople/objectives-and-data/browse-objectives/dementias/increase-proportion-adults-subjective-cognitive-decline-who-have-discussed-their-symptoms-provider-dia-03 (Accessed on: September 13, 2023).
[30]
Weinberger, A.H.; Wyka, K.; Goodwin, R.D. Impact of cannabis legalization in the United States on trends in cannabis use and daily cannabis use among individuals who smoke cigarettes. Drug Alcohol Depend., 2022, 238, 109563.
[http://dx.doi.org/10.1016/j.drugalcdep.2022.109563] [PMID: 35870333]

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