Title:Nanostructured Lipid Carriers: A Novel Platform in the Formulation of Targeted Drug Delivery Systems
Volume: 15
Issue: 1
Author(s): Naga Sri Devi Putchakayala, Keerthana Morusu*, Sireesha Ramisetty and Nagaraju Ravoru*
Affiliation:
- Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, India
- Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, India
Keywords:
Nanostructured lipid carriers (NLCs), design of experiments (DOE), box behnken design (BBD), plackett burman design, central composite design (CCD), response surface methodology (RSM).
Abstract:
Background: Lipid-based formulations, such as Nanostructured lipid carriers (NLCs),
have been thoroughly studied as drug delivery platforms. NLCs are binary systems composed of
both solid and liquid lipids that aim to produce a lipidic core that is less ordered. Components of
NLCs particularly influence the physicochemical characteristics and efficacy of the final product.
Morphology : They contain a solid matrix at room temperature and are thought to be superior to
many other conventional lipids-based nanocarriers, such as solid lipid nanoparticles (SLNs), nanoemulsions,
and liposomes because of their improved stability, drug loading capacity, good biocompatibility,
enhanced permeability, bioavailability, extended half-life, fewer side effects, tissue-
specific delivery and wide range of potential applications.
Significance : NLCs have multiple applications in the manufacturing of pharmaceuticals and cosmetics
due to their ease of preparation, the feasibility of scale-up, non-toxic, improved targeting efficiency
and potential for site-specific delivery via various routes of administration.
Scope of Review: This review enlightens about the most recent developments of NLCs as a drug
delivery system, types of NLCs, current techniques to prepare NLCs, and characterization techniques
that are essential for the development of safe, effective and stable formulation. It also encompasses
the potential of using NLCs for various administration routes and recent developments
in pharmaceutical applications with successful outcomes.
Conclusion: This review certainly provide great insight into formulation considerations using design
experts and modification strategies for improved targeting. On the whole, NLCs are broadly
explored and preferred lipid nanocarrier systems with several advantages.
