摘要
背景:血栓形成是多种血管疾病发病和死亡的主要原因之一。从药用植物中鉴定抗血栓药物已经进行了几项研究,酚类化合物(PCs)已被证明能有效地抑制血浆凝固和血小板聚集。 目的:本研究旨在对具有抗血栓和抗血小板活性的天然PC进行调查,并使用药物相似方法通过计算模型评估这些化合物的物理化学和毒理学特性。 方法:数据收集自科学数据库:“Web of Science”,“Scifinder”,“Pubmed”,“ScienceDirect”和“Google Scholar”,使用具有抗血栓或抗血小板作用的不同类型的pc作为关键词。这些分子还评估了它们的药物相似特性和毒性,以验证它们作为新的抗血栓药物候选物的概况。 结果:共登记到85种木脂素、73种黄酮类、28种香豆素、21种醌类、23种酚酸类、8种山酮类和8种简单酚类化合物。在所研究的数据库中未发现单宁的活性记录。在这246种化合物中,213种不违反Lipinski的5条规则,其中125种(59%)显示无毒,是潜在的抗血栓药物的有希望的候选者。 结论:这篇综述引起了人们对分离酚类化合物的兴趣,这可能为预防动脉和静脉血栓形成提供新的途径,并有可能成为预防和治疗心血管疾病的替代方法。
关键词: 酚类化合物,抗凝血剂,抗血小板,抗血栓,药物相似,生物信息学。
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