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Current Nutrition & Food Science

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Review Article

The Fascinating Effects of Flavonoids on Lung Cancer: A Review

Author(s): Dhirendra Singh, Meenakshi Dhanawat, Inderjeet Verma* and Sumeet Gupta

Volume 20, Issue 10, 2024

Published on: 16 February, 2024

Page: [1231 - 1251] Pages: 21

DOI: 10.2174/0115734013269110231113063044

Price: $65

Open Access Journals Promotions 2
Abstract

Lung cancer has emerged as one of the most often reported illnesses and leading causes of mortality worldwide. Inefficient, lack of safety, low therapeutic index, unpleasant effects, and excessive cost have led to a loss of trust in synthetic medications, limiting their use. Natural compounds have good anticancer potential without unwanted toxic effects. Among them, flavonoids are the most important compounds. Flavonoids are polyphenolic chemical compounds abundant in fruits and vegetables and are essential in preventing lung cancer. Their potent anticancer effects are said to be based on a wide range of biological actions, such as antioxidants, anti-mutagenesis, anti-inflammation, and differentiation induction, preventing cancer cell proliferation through regulating signal transduction pathways, triggering cell cycle arrest, and activating apoptosis or autophagy; anti-invasion; anti-metastasis, altering cancer cell drug resistance and increasing sensitization to chemotherapy. This review illustrates the most recent advancements in flavonoids in lung cancer and their associated molecular mechanisms using information from scientific research studies like in vitro and in vivo clinical trials. It takes these data into theory and practice.

Keywords: Flavonoids, lung cancer, oncogenic signaling, anticancer drugs, drug resistance, polyphenolic chemical.

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