Title:The Interplay of Comorbidities in Chronic Heart Failure: Challenges and
Solutions
Volume: 20
Issue: 3
Author(s): Shashipriya Agress, Jannat S. Sheikh, Aida A. Perez Ramos, Durlav Kashyap, Soha Razmjouei, Joy Kumar, Mankaranvir Singh, Muhammad Ali Lak, Ali Osman and Muhammad Zia ul Haq*
Affiliation:
- Department of Epidemiology and Public Health, Emory University Rollins School of Public Health, Atlanta, USA
- Department of Noncommunicable Diseases and Mental Health, World Health Organization, Cairo, Egypt
Keywords:
Chronic heart failure, comorbidity management, multidisciplinary approach, reduced ejection fraction, preserved ejection fraction, treatment standardization.
Abstract:
Background: Chronic heart failure (HF) is frequently associated with various comorbidities.
These comorbid conditions, such as anemia, diabetes mellitus, renal insufficiency, and
sleep apnea, can significantly impact the prognosis of patients with HF.
Objective: This review aims to synthesize current evidence on the prevalence, impact, and management
of comorbidities in patients with chronic HF.
Methods: A comprehensive review was conducted, with a rigorous selection process. Out of an
initial pool of 59,030 articles identified across various research modalities, 134 articles were
chosen for inclusion. The selection spanned various research methods, from randomized controlled
trials to observational studies.
Results: Comorbidities are highly prevalent in patients with HF and contribute to increased hospitalization
rates and mortality. Despite advances in therapies for HF with reduced ejection fraction,
options for treating HF with preserved ejection fraction remain sparse. Existing treatment
protocols often lack standardization, reflecting a limited understanding of the intricate relationships
between HF and associated comorbidities.
Conclusion: There is a pressing need for a multidisciplinary, tailored approach to manage HF
and its intricate comorbidities. This review underscores the importance of ongoing research efforts
to devise targeted treatment strategies for HF patients with various comorbid conditions.
