Title:Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention
and Treatment of Diseases: A Review
Volume: 24
Issue: 15
Author(s): Kanchan Bhardwaj, Rashi Bhargav, Jiri Patocka, Ruchi Sharma, Zdenka Navratilova, Patrik Oleksak and Kamil Kuca*
Affiliation:
- Department of
Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic
- Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech
Republic
Keywords:
Anxiety, autophagy, DNLA, oxidative stress, neuroinflammation, osteoclasts.
Abstract: A sesquiterpenic alkaloid dendrobine is the major bioactive compound extracted from
Dendrobium nobile Lindl. This compound was structurally very similar to picrotoxinin (neurotoxin)
containing bicyclic or tricyclic ring while dendrobine containing tetracyclic rings with up to 7 stereogenic
centers showing numerous neuroprotective effects. Several sesquiterpenic alkaloids such as
(+)-(1R,5R,6S,8R,9R)- 8,12-dihydroxy-copacamphan-3-en-2-one, dendrobine, denrine B, (+)-
(1R,2S,3R,4S,5R,6S,9R)-3,11,12-trihydroxypicrotoxane-2(15)-lactone, dendroxine B, nobilonine,
13-Hydroxy-14-oxodendrobine, 6-Hydroxy-nobilonine and (−)-(1S,2R,3S,4R,5S,6R,9S,12R)-
3,11,13-trihydroxypicrotoxane-2(15)-lactone were isolated from D. nobile This comprehensive review
summarizes the necessary information on the morphology, biochemistry and pharmacology of
dendrobine. The phytochemical profile had potent in-vivo and in-vitro efficacy in neuroprotection,
nerve function, memory enhancement, cognitive disorders, anxiety and depression, anti-oxidant,
psychological conditions, increasing serotonin concentration in synapse anxiolytic, tranquilizing,
anti-stress, neurodegenerative (Alzheimer’s disease and Parkinson), anti-inflammatory and analgesic.
The compound dendrobine activates neuro synapses, serotonergic synapse and signaling pathways
during neurotransmission playing important role in Alzheimer’s disease, Parkinson's disease,
anxiety and long-term depression.
