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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review

Author(s): Ashis Kumar Sahoo* and Aditya Bhattacharyya

Volume 28, Issue 3, 2024

Published on: 31 January, 2024

Page: [161 - 175] Pages: 15

DOI: 10.2174/0113852728285439240109071659

Price: $65

Abstract

Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various synthetic strategies and methodologies employed for the synthesis of tetrahydroquinoxaline scaffolds during this period. The review emphasizes the diverse synthetic approaches employed, including cycloaddition reactions, condensation reactions, intramolecular cyclization reactions, ring expansion reactions, hydrogenation reactions, and other miscellaneous methods.

Keywords: Tetrahydroquinoxalines, ring-expansion reactions, cycloadditions reaction, hydrogenation reactions, condensation reactions, intramolecular cyclization reactions.

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