Title:Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study
Volume: 18
Issue: 2
Author(s): Payman Bagheri, Majid Nouri, Hesam Eskandarzadeh and Mohammad Darvishi*
Affiliation:
- Aja University of Medical Sciences, Infectious Diseases and Tropical
Medicine Research Centre (IDTMRC), Department of Aerospace and Subaquatic Medicine, AJA University of Medical
Sciences, Tehran, Iran
Keywords:
Vitamin D3, IgE, chronic rhinosinusitis, allergic sinusitis, patients, deficiency.
Abstract:
Background: Chronic rhinosinusitis is known as a common problem with inflammatory
and allergic causes. Several factors are associated with developing chronic rhinosinusitis,
including immunoglobulin E (IgE) production and vitamin D deficiency.
Objective: In this study, we investigated the role of IgE and Vitamin D deficiency and differences
between patients with chronic, allergic sinusitis and controls.
Methods: A total of 90 subjects were included in 3 groups (n=30) in this cross-sectional, correlational
descriptive study. The subjects were divided into three groups, including control
(healthy subjects), chronic sinusitis patients, and allergy patients. A checklist was used to collect
the necessary data, including age, gender, and body mass index (BMI). To evaluate serum
levels of vitamin D3 and IgE, ELISA kits were used.
Results: The mean vitamin D was 22 g/ml. Fifty-four participants (60%) out of all included
people had insufficient vitamin D, 13% had a deficiency, and the high deficiency and insufficiency
were in the group of allergic sinusitis. Our results indicated that gender (female) was
significantly associated with vitamin D deficiency (p =0.01). Thirty-nine participants (43.3%)
out of all studied subjects had high IgE, and the highest level of abnormality of IgE was in the
allergic sinusitis group. Furthermore, it was found that gender and IgE were not significantly
related. However, IgE was significantly associated with vitamin D deficiency in the allergic sinusitis
group.
Conclusion: Our findings highlighted that most of the patients with chronic and allergic sinusitis
had insufficient vitamin D. A possible association was also found between low vitamin D
and IgE levels and the prevalence of allergic sinusitis. This study showed that patients with allergic
sinusitis may be more vulnerable to lower serum levels of vitamin D. Therefore, vitamin
D supplementation as an adjunctive therapy may be considered in these patients.
