Title:The Role of Prebiotic, Probiotic, and Synbiotic in Gut Microbiota and Gut
Permeability in Children Affected by Air Pollution
Volume: 20
Issue: 10
Author(s): Andy Darma, Dian Kusuma Dewi, Dian Novita Chandra, Ray Wagiu Basrowi*, Levina Chandra Khoe, Dessy Pratiwi and Tonny Sundjaya
Affiliation:
- Occupational Medicine Study Program, Faculty of Medicine,
Universitas Indonesia, Jakarta, Indonesia
- Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia,
Yogyakarta, Indonesia
Keywords:
Prebiotic, probiotic, symbiotic, pollution, pediatric, gut microbiota, dysbiosis.
Abstract:
Background: Air pollution has been linked with gut microbiota dysbiosis. Ingested environmental
pollutants may alter gut microbiota compositions by changing the environment of the
gut. Gut microbiota dysbiosis has been observed in children with asthma, linking the possible role
of gut microbiota with systemic immune response and asthma.
Methods: This paper aims to identify current science on how prebiotics, probiotics, and synbiotics
can improve gut microbiota dysbiosis.
Results: We reviewed the existing literature related to the role of pre-, pro-, and synbiotics in
child health, and the evidence mapping method was chosen as the rapid review to identify gaps in
knowledge and future research needs.
Conclusion: In conclusion, the current evidence on the role of prebiotics, probiotics, and synbiotics
on child health, while limited, showed promising results on the allergy and immunology pathway,
including infection prevention for the gastrointestinal and respiratory tract.
