Title:Advancements in the Research of GEF-H1: Biological Functions and Tumor
Associations
Volume: 17
Author(s): Liqi Li, Yunyun Li*Xiaoshu Zhou*
Affiliation:
- Department of Neurology, The 942 Hospital of PLA, Yinchuan, Ningxia Hui Autonomous Region, 750001, China
- College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China
Keywords:
GEF-H1, Rho GTPase, Guanine nucleotide exchange factor, ARHGEF2, Cancer, RhoA.
Abstract: Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase
family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various
pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular
barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor
microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological
roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.
