Abstract
Background: Nicosulfuron, a widely used herbicide in crops, has raised concerns due to its escalating presence as an environmental pollutant, particularly in soil and water. The potential adverse effects of nicosulfuron on animals, including reproductive toxicity, have garnered attention.
Objective: The study aimed to evaluate the reproductive toxicity of nicosulfuron in male mice.
Methods: Male mice were orally administrated with three different concentration gradients (350, 700, and 1400 mg/kg) of nicosulfuron for 35 days. The investigation delved into sperm quality, testicular structures, and expression of cleaved caspase-3 and NF-κB p65 of the testes.
Results: The finding unveiled a correlation between nicosulfuron exposure and detrimental effects on sperm quality and alteration of testicular structure. Notably, parameters, such as sperm survival rate (SUR) and sperm motility (MOT), exhibited a decline in relation to increasing nicosulfuron dosages. Moreover, in the mice subjected to higher doses of nicosulfuron, elevated expression of cleaved caspase-3 and NF-κB p65 was observed in the testes. Interestingly, we also observed an increase of NF-κB p65 expression in the mice exposed to the nicosulfuron.
Conclusion: Our research revealed that exposure to nicosulfuron resulted in compromised sperm quality and alterations in testicular structure. The correlation between nicosulfuron and apoptosis, especially via the NF-κB pathway, provided significant insights into the mechanisms underpinning these detrimental effects. These findings significantly enhance our comprehension of the potential hazards associated with nicosulfuron exposure and its impacts on the reproductive health of animals.
Keywords: Nicosulfuron, Reproductive toxicity, Poor quality sperm, Cell apoptosis, Cleaved caspase-3, NF-κB pathway.
Current Molecular Pharmacology
Title:Impact of Nicosulfuron on Sperm Quality: Insights into Testicular Cell Apoptosis and NF-κB Signaling Pathway in Mice Testes
Volume: 17
Author(s): Jianqiu Han, Chen Zhao, Qing Shen, Yalei Qi, Yanjia Zhang, Faisal Raza, Yongmei Li, Hajra Zafar, Tengfei Liu, Juan Tan*, Honghui Han*Xueyun Ma*
Affiliation:
- Shanghai Key Laboratory of Brain Functional Genomics, Ministry of Education of Life Sciences, East China Normal University, Shanghai, China
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
Keywords: Nicosulfuron, Reproductive toxicity, Poor quality sperm, Cell apoptosis, Cleaved caspase-3, NF-κB pathway.
Abstract:
Background: Nicosulfuron, a widely used herbicide in crops, has raised concerns due to its escalating presence as an environmental pollutant, particularly in soil and water. The potential adverse effects of nicosulfuron on animals, including reproductive toxicity, have garnered attention.
Objective: The study aimed to evaluate the reproductive toxicity of nicosulfuron in male mice.
Methods: Male mice were orally administrated with three different concentration gradients (350, 700, and 1400 mg/kg) of nicosulfuron for 35 days. The investigation delved into sperm quality, testicular structures, and expression of cleaved caspase-3 and NF-κB p65 of the testes.
Results: The finding unveiled a correlation between nicosulfuron exposure and detrimental effects on sperm quality and alteration of testicular structure. Notably, parameters, such as sperm survival rate (SUR) and sperm motility (MOT), exhibited a decline in relation to increasing nicosulfuron dosages. Moreover, in the mice subjected to higher doses of nicosulfuron, elevated expression of cleaved caspase-3 and NF-κB p65 was observed in the testes. Interestingly, we also observed an increase of NF-κB p65 expression in the mice exposed to the nicosulfuron.
Conclusion: Our research revealed that exposure to nicosulfuron resulted in compromised sperm quality and alterations in testicular structure. The correlation between nicosulfuron and apoptosis, especially via the NF-κB pathway, provided significant insights into the mechanisms underpinning these detrimental effects. These findings significantly enhance our comprehension of the potential hazards associated with nicosulfuron exposure and its impacts on the reproductive health of animals.
Export Options
About this article
Cite this article as:
Han Jianqiu, Zhao Chen, Shen Qing, Qi Yalei, Zhang Yanjia, Raza Faisal, Li Yongmei, Zafar Hajra, Liu Tengfei, Tan Juan*, Han Honghui*, Ma Xueyun*, Impact of Nicosulfuron on Sperm Quality: Insights into Testicular Cell Apoptosis and NF-κB Signaling Pathway in Mice Testes, Current Molecular Pharmacology 2024; 17 : e18761429282063 . https://dx.doi.org/10.2174/0118761429282063231119180457
DOI https://dx.doi.org/10.2174/0118761429282063231119180457 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
Call for Papers in Thematic Issues
Common mechanisms underpinning neurodevelopmental disorders and psychiatric diseases
A growing number of large-scale epidemiologic studies has strongly suggested that common mechanisms may be shared by aberrant brain development and psychiatric disorders. There is now an appreciation of synergic roles of genetic variants and environmental stress which profoundly affect the genome integrity and reshape brain development. This can lead ...read more
Pharmacology and Toxicology of Plant Bioactive Compounds
The thematic issue "Pharmacology and Toxicology of Plant Bioactive Compounds" aims to explore the multifaceted aspects of bioactive compounds derived from plants, delving into their pharmacological properties and potential toxicological implications. This issue will encompass a wide array of research, including investigations into the therapeutic benefits of plant-derived compounds, such ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Neuropharmacological Effects of Magnolol and Honokiol: A Review
of Signal Pathways and Molecular Mechanisms
Current Molecular Pharmacology Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease
Current Pharmaceutical Design Heme Oxygenase-1/Carbon Monoxide: Novel Therapeutic Strategies in Critical Care Medicine
Current Drug Targets Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis
Current Pharmaceutical Design Adrenomedullin: Roles for Structure and Function in Cardiac or Vascular Tissues
Current Hypertension Reviews Effect of Doxycycline on Atherosclerosis: From Bench to Bedside
Recent Patents on Cardiovascular Drug Discovery Perspective of MiRNAs in Clinical Glioblastoma Research
Current Signal Transduction Therapy Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis
Current Neuropharmacology Glycogen Synthase Kinase-3 (GSK-3) Inhibitors for the Treatment of Alzheimers Disease
Current Pharmaceutical Design In-Silico Analysis and Molecular Docking Studies of Potential Phosphodiesterase 4 Inhibitors using Ventilago Isolates
Letters in Organic Chemistry A Model on the Induction of Adverse Vascular Long-Term Effects of NSAIDs
Medicinal Chemistry Undiagnosed Intra-articular Synovial Hemangioma: A Rare Cause of Knee Pain and Swelling
Current Rheumatology Reviews Perspectives for Novel Mixed Diruthenium-Organic Drugs as Metallopharmaceuticals in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry microRNA Biogenesis Pathway as a Therapeutic Target for Human Disease and Cancer
Current Pharmaceutical Design Recent Updates on Peptide Molecules in Drug and Vaccine Development
Current Pharmaceutical Design Paeoniflorin Alleviates Anxiety and Visceral Hypersensitivity <i>via</i> HPA Axis and BDNF/TrkB/PLCγ1 Pathway in Maternal Separation-induced IBS-like Rats
Current Molecular Pharmacology Turning Up the Pressure on Vascular Disease
Current Neurovascular Research Editorial [ The Importance of Raising the Profile of Alcohol Hangover Research ]
Current Drug Abuse Reviews Bioavailability of Endomorphins and the Blood-brain Barrier- A Review
Medicinal Chemistry Human Mesenchymal Stem Cells (hMSCs) as Targets of DNA Damaging Agents in Cancer Therapy
Current Cancer Drug Targets