Title:Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound
Synthesis
Volume: 28
Issue: 13
Author(s): Alcione S. de Carvalho, Gabriel R.M. de Freitas, Caroline D. Nicoletti, Fernando de C. da Silva, Débora O. Futuro, Vitor F. Ferreira*Patricia G. Ferreira*
Affiliation:
- Programa de Pós-Graduação em Ciências Aplicadas a Produtos para a Saúde, Faculdade de Farmácia, Universidade Federal
Fluminense, R., Dr. Mario Vianna, 523, Niterói-RJ, 24241-000, Brasil
- Programa de Pós-Graduação em Ciências
Aplicadas a Produtos para a Saúde, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal
Fluminense, R., Dr. Mario Vianna, 523, Niterói-RJ, CEP 24241-000, Brasil
- Programa de Pós-Graduação em Ciências Aplicadas a Produtos para a Saúde, Faculdade de Farmácia, Universidade Federal
Fluminense, R., Dr. Mario Vianna, 523, Niterói-RJ, 24241-000, Brasil
Keywords:
Biologically active molecules, natural products, sporotrichosis, drug repurposing, tropical disease, traumatic exposure.
Abstract: Sporotrichosis, recognized by the World Health Organization (WHO) as a neglected
tropical disease and classified among significant fungal health concerns, remains
both underestimated and underreported. There is a profound impact of sporotrichosis on
public health, affecting both humans and domestic animals. The causative agents are fungi
within the Sporothrix genus, primarily transmitted through traumatic exposure to contaminated
soil, plants, decomposing materials, or through scratches from infected animals, notably
cats. While sporotrichosis is a global concern, its prevalence is particularly noteworthy
in tropical and subtropical regions. The limited treatment options for sporotrichosis, with
itraconazole as the preferred choice, underscore the challenges posed by fungal infections.
Issues such as toxicity and drug resistance further complicate effective management. Consequently,
this review aims to elucidate key objectives: identification of novel synthetic compounds revealed in
the literature, highlighting ongoing efforts to develop new treatments against sporotrichosis, examining promising
anti-sporothrix natural products, and providing an overview of endeavors to repurpose approved drugs. The
key findings from the study underscore the urgent need for diversified and effective drugs for the treatment of
Sporotrichosis.
