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Review Article

Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation

Author(s): Mengyu Zhang, Xiaoyun Ji, Yuxin Li, Xin Chen, Xiaoqing Wu, Rui Tan* and Hezhong Jiang*

Volume 24, Issue 12, 2024

Published on: 26 January, 2024

Page: [1162 - 1176] Pages: 15

DOI: 10.2174/0113895575271848231116095447

Price: $65

Open Access Journals Promotions 2
Abstract

Anthriscus sylvestris (L.) Hoffm. Gen. is a biennial or perennial herb commonly found in China. It has a long history of use in traditional Chinese medicine to treat various ailments such as cough, gastric disorders, spleen deficiency, and limb weakness. Recently, its potential as an anticancer agent has gained considerable attention and has been the subject of extensive research focusing on extract efficacy, identification of active compounds, and proposed molecular mechanisms. Nevertheless, further high-quality research is still required to fully evaluate its potential as an anticancer drug.

This review aims to comprehensively summarize the anticancer properties exhibited by the active components found in Anthriscus sylvestris.

We conducted a comprehensive search, collation, and analysis of published articles on anticancer activity and active compounds of A. sylvestris using various databases that include, but are not limited to, PubMed, Web of Science, Science Direct and Google Scholar.

The primary chemical composition of A. sylvestris consists of phenylpropanoids, flavonoids, steroids, fatty acids, and organic acids, showcasing an array of pharmacological activities like anticancer, antioxidant, anti-aging, and immunoregulatory properties. Thus, this review highlights the active compounds isolated from A. sylvestris extracts, which provide potential leads for the development of novel anticancer drugs and a better understanding of the plant's pharmacological effects, particularly its anticancer mechanism of action.

Keywords: Anthriscus sylvestris, Chemical constituents, anticancer mechanism, petroleum ether extract, Anthricin, modern investigation.

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