Effect of Geraniol against the Toxicity Induced by Paracetamol in the Third Instar Larvae of Transgenic Drosophila Melanogaster (hsp70-lac Z)Bg⁹

Title:Effect of Geraniol against the Toxicity Induced by Paracetamol in the Third Instar Larvae of Transgenic Drosophila Melanogaster (hsp70-lac Z)Bg⁹

Volume: 19 Issue: 7

Author(s): Iqra Subhan, Sumbul Khan, Himanshi Varshney, Kajal Gaur and Yasir Hasan Siddique*

Affiliation:

• Department of Zoology, Laboratory of Alternative Animal Models, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India

Keywords: Geraniol, drosophila, paracetamol, oxidative stress, toxicity, non-steroidal and anti-inflammatory drug (NSAID).

Abstract:

Background: Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants. It is commercially used as a fragrance compound in cosmetics and several products of a household. It possesses a number of biological properties.

Objective: To study the effect of geraniol on the toxicity induced by paracetamol.

Method: In the present study, geraniol at the final concentration of 0.0005, 0.0025, 0.0050 and 0.0075 M was mixed in the diet along with the 0.0075 M of paracetamol and the third instar larvae of transgenic Drosophila melanogaster (hsp70-lac Z)Bg9 were allowed to feed on it for 24 hrs.

Result: Larvae exposed to paracetamol along with the various doses of geraniol showed a dosedependent decrease in the activity of β-galactosidase, tissue damage, oxidative stress markers, DNA damage and apoptosis. The results suggest that geraniol is potent in reducing the toxicity induced by paracetamol in the third instar larvae of transgenic Drosophila

Conclusion: Hence, it is concluded that paracetamol showed toxic effects in the third instar larvae of transgenic Drosophila, and geraniol is potent in reducing the toxic effects induced by paracetamol.

Cite this article as:

Subhan Iqra, Khan Sumbul, Varshney Himanshi, Gaur Kajal and Siddique Hasan Yasir*, Effect of Geraniol against the Toxicity Induced by Paracetamol in the Third Instar Larvae of Transgenic Drosophila Melanogaster (hsp70-lac Z)Bg⁹, Current Drug Therapy 2024; 19 (7) . https://dx.doi.org/10.2174/0115748855272494240109103657