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Current Drug Therapy

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ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

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Research Article

Effect of Geraniol against the Toxicity Induced by Paracetamol in the Third Instar Larvae of Transgenic Drosophila Melanogaster (hsp70-lac Z)Bg9

Author(s): Iqra Subhan, Sumbul Khan, Himanshi Varshney, Kajal Gaur and Yasir Hasan Siddique*

Volume 19, Issue 7, 2024

Published on: 26 January, 2024

Page: [851 - 862] Pages: 12

DOI: 10.2174/0115748855272494240109103657

Price: $65

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Abstract

Background: Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants. It is commercially used as a fragrance compound in cosmetics and several products of a household. It possesses a number of biological properties.

Objective: To study the effect of geraniol on the toxicity induced by paracetamol.

Methods: In the present study, geraniol at the final concentration of 0.0005, 0.0025, 0.0050 and 0.0075 M was mixed in the diet along with the 0.0075 M of paracetamol and the third instar larvae of transgenic Drosophila melanogaster (hsp70-lac Z)Bg9 were allowed to feed on it for 24 hrs.

Results: Larvae exposed to paracetamol along with the various doses of geraniol showed a dosedependent decrease in the activity of β-galactosidase, tissue damage, oxidative stress markers, DNA damage and apoptosis. The results suggest that geraniol is potent in reducing the toxicity induced by paracetamol in the third instar larvae of transgenic Drosophila.

Conclusion: Hence, it is concluded that paracetamol showed toxic effects in the third instar larvae of transgenic Drosophila, and geraniol is potent in reducing the toxic effects induced by paracetamol.

Keywords: Geraniol, drosophila, paracetamol, oxidative stress, toxicity, non-steroidal, anti-inflammatory drug (NSAID).

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