Title:Alnustone: A Review of its Sources, Pharmacology, and Pharmacokinetics
Volume: 17
Author(s): Zahra Salari, Maryam Alavi, Hojjat Rezaii-zadeh, Abdelhakim Bouyahya, Ammar Alfergah, Sahar Afsari Sardari and Ehsan Amiri Ardekani*
Affiliation:
- Students Research Committee, Shiraz University of Medical Sciences, Shiraz 71348, Iran
- Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz 71348, Iran
- Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz 71348, Iran
Keywords:
Alnustone, Pharmacology, Pharmacokinetics, Review, Complementary medicine, Alternative medicine.
Abstract:
Alnustone (4(E)-,6(E)-1,7-Diphenyl-hepta-4,6-dien-3-one) is a non-phenolic natural diarylheptanoid, which was first isolated and identified from
the male flower of Alnus pendula (Betulaceae). It can also be isolated from Curcuma xanthorrhiza Roxb (Zingiberaceae) rhizomes and Alpinia
katsumadai Hayata (Zingiberaceae) seeds. It was first synthesized through a five-step process from β-phenyl propionyl chloride. In later years, new
methods for synthesizing Alnustone were designed and performed with different yields. Due to the various therapeutic effects exhibited by
alnustone like other diarylheptanoids, its biological activities such as antioxidant, antibacterial, and anti-inflammatory properties have been the
subject of many studies.
This article has reviewed different aspects of this valuable natural compound, including its natural and synthetic sources, therapeutic effects, and
pharmacokinetics as a potential future therapeutic agent.
