Title:Effect of HPV Oncoprotein on Carbohydrate and Lipid Metabolism in
Tumor Cells
Volume: 24
Issue: 10
关键词:
碳水化合物代谢，脂质代谢，宫颈癌，HPV，信号通路，癌蛋白。
摘要: High-risk HPV infection accounts for 99.7% of cervical cancer, over 90% of anal cancer,
50% of head and neck cancers, 40% of vulvar cancer, and some cases of vaginal and penile
cancer, contributing to approximately 5% of cancers worldwide. The development of cancer is a
complex, multi-step process characterized by dysregulation of signaling pathways and alterations
in metabolic pathways. Extensive research has demonstrated that metabolic reprogramming plays
a key role in the progression of various cancers, such as cervical, head and neck, bladder, and prostate
cancers, providing the material and energy foundation for rapid proliferation and migration of
cancer cells. Metabolic reprogramming of tumor cells allows for the rapid generation of ATP, aiding
in meeting the high energy demands of HPV-related cancer cell proliferation. The interaction
between Human Papillomavirus (HPV) and its associated cancers has become a recent focus of investigation.
The impact of HPV on cellular metabolism has emerged as an emerging research topic.
A significant body of research has shown that HPV influences relevant metabolic signaling
pathways, leading to cellular metabolic alterations. Exploring the underlying mechanisms may facilitate
the discovery of biomarkers for diagnosis and treatment of HPV-associated diseases. In
this review, we introduced the molecular structure of HPV and its replication process, discussed
the diseases associated with HPV infection, described the energy metabolism of normal cells, highlighted
the metabolic features of tumor cells, and provided an overview of recent advances in potential
therapeutic targets that act on cellular metabolism. We discussed the potential mechanisms
underlying these changes. This article aims to elucidate the role of Human Papillomavirus (HPV)
in reshaping cellular metabolism and the application of metabolic changes in the research of related
diseases. Targeting cancer metabolism may serve as an effective strategy to support traditional
cancer treatments, as metabolic reprogramming is crucial for malignant transformation in cancer.
