Title:Nanostructures and Niosomes: A Quantum Leap in Clotrimazole Therapeutics
Volume: 19
Author(s): Himanshu Gupta*, Jitendra Singh Chaudhary and Dilip Kumar Chanchal
Affiliation:
- Department of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India
Keywords:
Clotrimazole, niosomes, nanostructures, drug delivery, antifungal therapy, dermatology.
Abstract: This in-depth analysis examines the revolutionary potential of nanostructures, particularly
niosomes, in boosting Clotrimazole's therapeutic effectiveness for dermatological applications. A
common antifungal drug called clotrimazole suffers significant problems with solubility, bioavailability,
and penetration. Niosomal gels in particular, which are nanostructured drug carriers, have
emerged as ground-breaking approaches to overcome these constraints. The study opens with an explanation
of the mechanisms of action of Clotrimazole and its wide range of therapeutic uses in dermatology,
emphasising the limitations of standard formulations. We present and explore niosomes,
lipid-based nanocarriers with diverse characteristics. They provide a viable substrate for improved
Clotrimazole administration due to their biocompatibility, adjustable lipid composition, and capacity
to encapsulate both hydrophilic and hydrophobic medications. The creation and development of clotrimazole-
loaded niosomal gels are at the core of the review. Numerous preparation processes are
investigated, and elements affecting the formation of niosomal gel, such as lipid content and optimization
strategies, are reviewed. Particle size analysis and encapsulation efficiency testing are two
methods for characterising these gels that are covered in depth. The effectiveness of Clotrimazoleloaded
niosomal gels is validated in large part by in vitro and in vivo tests. The review explores in
vitro drug release investigations, studies of skin permeability and penetration, and comparisons with
conventional formulations. When accessible, preclinical and clinical trial insights provide crucial
clinical context. The benefits of clotrimazole-loaded niosomal gels, such as greater patient compliance
and improved drug delivery, are also covered in the article. It solves difficulties including stability
issues and regulatory issues. The review's conclusion emphasises the essential role that
nanostructures and niosomes have played in developing Clotrimazole medicines for dermatological
usage. It provides a thorough review of current developments, exciting new approaches, and the wider
effects of this ground-breaking medication delivery strategy.
