Title:Recent Progress in the Application of Exosome Analysis in Ovarian
Cancer Management
Volume: 24
Issue: 9
Author(s): Vahideh Keyvani, Zari Naderi Ghale-Noie, Samaneh Mollazadeh, Reihaneh Alsadat Mahmoudian, Elnaz Ghorbani, Hamid Naderi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan*Kazem Anvari*
Affiliation:
- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- Faculty of Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, 4059, Australia
- College of Medicine and Health Sciences, National University of Science and Technology, Sultanate of Oman
- Cancer Research Center, Mashhad
University of Medical Sciences, Mashhad, Iran
Keywords:
Ovarian cancer, exosomes, bioactive molecules, biomarkers, delivery vehicles, extracellular vesicles.
Abstract: Exosomes are very small (nano-sized) vesicles participating in tumor development by
involvement in intercellular communication mediated by transferring biocomponents. Exosomes
appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy
in women. Several hallmarks of ovarian cancer are reported to be affected by the exosomemediated
cellular cross-talk, including modulating peritoneal dissemination and chemoresistance.
Since the expression of some biomolecules, such as miRNAs and mRNA, is changed in ovarian
cancer, these exo-biomolecules can be applied as prognostic, diagnostic, and therapeutic biomarkers.
Also, the selective loading of specific chemotherapeutic agents into exosomes highlights these
biocarries as potential delivery devices. Exosomes could be artificially provided and engineered to
better target the site of interest in ovarian cancer. In the present review, we summarize the notable
achievement of exosome application in ovarian cancer management to gain applicable transitional
insight against this cancer.