Title:Light Sensitive Liposomes: A Novel Strategy for Targeted Drug Delivery
Volume: 13
Issue: 1
Author(s): Chintan Aundhia*, Ghanshyam Parmar, Chitrali Talele, Dipali Talele and Avinsh Kumar Seth
Affiliation:
- Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760,
Gujarat, India
Keywords:
Drug delivery system, light sensitive liposomes, photosensitive liposomes, targeted drug delivery, nanocarriers, lipid bilayers.
Abstract: Light-sensitive liposomes have emerged as a promising platform for drug delivery, offering
the potential for precise control over drug release and targeted therapy. These lipid-based nanoparticles
possess photoresponsive properties, allowing them to undergo structural changes or release
therapeutic payloads upon exposure to specific wavelengths of light. This review presents an overview
of the design principles, fabrication methods, and applications of light-sensitive liposomes in
drug delivery. Further, this article also discusses the incorporation of light-sensitive moieties, such as
azobenzene, spiropyran, and diarylethene, into liposomal structures, enabling spatiotemporal control
over drug release. The utilization of photosensitizers and imaging agents to enhance the functionality
and versatility of light-sensitive liposomes is also highlighted. Finally, the recent advances, challenges,
and future directions in the field, emphasizing the potential for these innovative nanocarriers to
revolutionize targeted therapeutics, are also discussed.
