Title:The Know-how of Polymeric Nanocarrier Based Vaginal Drug Delivery
System: Pitfalls, Challenges and Trends
Volume: 12
Author(s): Pranita Kanojiya, Rita Wadetwar*, Megha Karemore and Satyendra Prasad
Affiliation:
- Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur-
440033, Maharashtra, India
Keywords:
Vaginal delivery, Polymeric nanoparticles, Mucoadhesive nanoparticles, PEGylated nanocarriers, Nanofiber, Nanoparticle in film.
Abstract:
Objective: Gynecological health is a global concern, and thus, the formulator researcher
strives to improve the quality of life through innovative feminine pharmaceutical formulations. Vaginal
delivery appears to be one of the vital strategies for local and systemic action of the therapeutically
active agent. The rich vascular network, mucosal permeability, bypass of hepatic first-pass effect,
and low enzymatic activity are the exclusive advantages of the vaginal route. But certain hindrances
truncate the vaginal route, such as physiological factors including lower pH, self-cleansing
mucus with constant secretion, and varying thickness of mucus layer due to menstrual cycle and microbiota.
Significance of Review: This present review envisages the advances in the polymeric nanocarriers
in the delivery to the vaginal route. Polymeric (mucoadhesive and PEGylated, etc.) nanocarriers
have been recently utilized for drug delivery purposes. The modernized analysis of the updated advancements
in the polymeric nanocarrier-based vaginal drug delivery system with the budding development
is compiled in the present review.
Result: The literature search reveals that the novel polymeric nanocarrier design strategies currently
being proposed to perk up the delivery of customary drugs through the vaginal route prove effective.
Conclusion: Polymeric nanocarrier for vaginal delivery has provided better therapeutic efficacy due
to higher drug residence, improved permeation, and sustained release of the active therapeutic agent.
The polymeric nanocarriers can deliver different proteins, peptides, nuclear materials, hormones,
etc., vaginally that are difficult for administration.
