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Letters in Organic Chemistry

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ISSN (Online): 1875-6255

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Research Article

Novel Amide Functionalized Trifluoromethyl thieno[2,3-b]pyridine Derivatives: Anti-cancer Activity and Molecular Docking Studies

Author(s): Sailu Betala*, Naveen Puram and Udayasri Bhanothu

Volume 21, Issue 7, 2024

Published on: 24 January, 2024

Page: [575 - 582] Pages: 8

DOI: 10.2174/0115701786272432231211100408

Price: $65

Abstract

Our primary research objective is to create and formulate small ring heterocycles with enhanced biological efficacy. Amide functionalized trifluoromethyl thieno[2,3-b]pyridine derivatives as a series were prepared starting from reaction between 1,3 di-ketone and thiocyanoacetamide and obtained pyridine 3. Compound 3 reacts with bromoethyl acetate and obtained compound 4, further compound 4 on reaction with diverse substituted aromatic and aliphatic amines to get amide derivatives 5a-d, 6a-d and 7a-h. All the final compounds evaluated for anti cancer activity against four human cancer cell lines such as ‘HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL- 222); HepG2 - Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22)’ and promising compounds 7d, 7e and 7f have been identified. For compounds 7d, 7e and 7f molecular docking interactions have been identified.

Keywords: Thieno pyridine, amide derivatives, molecular docking interactions, breast cancer, heterocyclic compounds, anticancer activity.

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