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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

靶向甲羟戊酸途径和自噬在抗肿瘤免疫治疗中的作用

卷 24, 期 9, 2024

发表于: 24 January, 2024

页: [890 - 909] 页: 20

弟呕挨: 10.2174/0115680096273730231206054104

价格: $65

摘要

目前，消化系统肿瘤是全球癌症相关死亡的主要原因之一。尽管肿瘤免疫治疗取得了相当大的进展，但大多数患者的预后仍然很差。在肿瘤微环境(tumor microenvironment, TME)中，肿瘤细胞通过免疫编辑实现免疫逃逸，获得免疫耐受。甲羟戊酸途径和自噬在肿瘤生物学、抗肿瘤免疫和TME调控中发挥重要作用。此外，这两种途径之间存在代谢串扰。然而，它们在消化系统肿瘤中促进免疫耐受的作用尚未得到总结。因此，本文就甲羟戊酸途径与自噬的肿瘤生物学、TME的调控、途径间的代谢串扰及其作为靶向抑制剂在临床肿瘤免疫治疗中的疗效评价作一综述。

关键词: 甲羟戊酸途径，自噬，代谢串扰，抗肿瘤免疫治疗，肿瘤微环境，消化系统。

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