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Current Organocatalysis

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ISSN (Online): 2213-3380

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Research Article

Glucose-Water Synergy: An Organocatalytic System Driven synthesis of Benzimidazolo[2,3-b]quinazolinone and Benzothiazolo[2,3-b]quinazolinone Derivatives

Author(s): Jyoti Baranwal, Swastika Singh, Smriti Kushwaha and Archana Jyoti*

Volume 11, Issue 3, 2024

Published on: 24 January, 2024

Page: [205 - 213] Pages: 9

DOI: 10.2174/0122133372274183231218063119

Price: $65

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Abstract

Introduction: A simple and efficient one-pot synthesis of quinazolinone derivatives has been developed via a multicomponent reaction (MCR) involving the condensation of dimedone, benzaldehyde, and 2-aminobenzimidazole/2-aminobenzothiazole.

Method: In this work, glucose water is used as a green, reusable, environmentally benign organocatalytic solvent system to synthesize desired products.

Result: The main benefits of this one-pot method include its excellent yields, less time, cost-effectiveness, atom economy, environment benign, and easy workup.

Conclusion: In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of benzimidazo/benzothiazolo quinazolinones using glucose water as an organocatalytic medium.

Keywords: Benzimidazolo[2, 3-b]quinazolinone, benzothiazolo[ 2, 3 - b ]quinazolinone, green organocatalytic system, heterocyclic compounds, glucose-water synergy, multicomponent reaction (MCR).

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