Title:Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy
Volume: 13
Issue: 1
Author(s): Sunny Shah, Harshida Chauhan, Hardik Madhu, Dhaval Mori, Moinuddin Soniwala, Sudarshan Singh*Bhupendra Prajapati*
Affiliation:
- Office of Research Administration, Chiang Mai University, Chiang Mai, 50200, Thailand
- Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand
- Shree. S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva,
384012, Gujarat, India
Keywords:
Nano-formulations, phytopharmaceuticals, phosphatidylcholine, solubility, bioavailability, conventional delivery techniques.
Abstract: Phytopharmaceuticals, derived from natural sources, manifest tremendous potential for
therapeutic applications. Nevertheless, effective delivery of these bio-actives presents significant
challenges. A breakthrough in fortifying phytopharmaceuticals within phosphatidylcholine is a
promising remedy to overcome solubility, permeability, and other related drawbacks. This intrinsic
lipid, which is obtained from both natural and synthetic sources, confers numerous benefits, encompassing
heightened solubility, augmented bioavailability, and enhanced stability. The conjugation of
phytopharmaceuticals with phosphatidylcholine enables improved dermal permeation, absorption,
targeted distribution, and the possibility of synergistic results, eventually improving therapeutic efficacy.
Additionally, the use of phytopharmaceuticals enriched with phosphatidylcholine presents a
promising route for overcoming the limitations imposed by conventional delivery techniques, encouraging
more effective treatments. The review provides a thorough analysis of phosphatidylcholine-
incorporated phytopharmaceuticals as nanomedicine with variables that significantly affect their
therapeutic efficacy. Moreover, the review elaborates on how phosphatidylcholine improves solubility,
permeability, and tissue distribution and boosts the potential of phytopharmaceuticals. Further,
the review underscores the significance of nano-formulation strategies, analytical methodologies, and
forthcoming prospects to propel this field forward. Furthermore, the review emphasizes the potential
inherent in this innovative approach while highlighting the importance of additional research endeavors
and collaborative initiatives to unlock the therapeutic benefits of phosphatidylcholinefortified
phytopharmaceuticals, enhancing patient well-being.
