Title:Roles of Mesenchymal Stem Cells in Breast Cancer Therapy:
Engineered Stem Cells and Exosomal Cell-Free Based Therapy
Volume: 24
Author(s): Mohsen Karami Fath, Seyed Sajjad Zadian, Samaneh Mohammad Bagherzadeh Torbati, Vahid Saqagandomabadi, Omid Yousefi Afshar, Mohammad Khalilzad, Sara Abedi, Afshin Moliani and Ghasem Barati*
Affiliation:
- Stem Cell Technology
Research Center, Tehran, Iran
Keywords:
Mesenchymal stem cells, breast cancer, genetic modification, extracellular vesicle, cancer therapy, cell therapy, cell-free therapy
Abstract: Breast cancer has a high prevalence among women, with a high mortality
rate. The number of people who suffer from breast cancer disease is increasing,
whereas metastatic cancers are mostly incurable, and existing therapies have
unfavorable side effects. For an extended duration, scientists have dedicated their
efforts to exploring the potential of mesenchymal stem cells (MSCs) for the treatment
of metastatic cancers, including breast cancer. MSCs could be genetically engineered
to boost their anticancer potency. Furthermore, MSCs can transport oncolytic viruses,
suicide genes, and anticancer medicines to tumors. Extracellular vesicles (EVs) are
MSC products that have attracted scientist's attention as a cell-free treatment. This
study narratively reviews the current state of knowledge on engineered MSCs and their
EVs as promising treatments for breast cancer.
