The Role of Long Noncoding RNAs in Progression of Leukemia: Based on
Chromosomal Location

Fatemeh      Sabaghi; Saina   Yousefi   Sadat; Zohreh      Mirsaeedi; Aref      Salahi; Sara      Vazifehshenas; Neda   Zahmat   Kesh; Mahdieh      Balavar; Pegah      Ghoraeian
doi:10.2174/0122115366265540231201065341
Abstract

Long non-coding RNA [LncRNA] dysregulation has been seen in many human cancers, including several kinds of leukemia, which is still a fatal disease with a poor prognosis. LncRNAs have been demonstrated to function as tumor suppressors or oncogenes in leukemia. This study covers current research findings on the role of lncRNAs in the prognosis and diagnosis of leukemia. Based on recent results, several lncRNAs are emerging as biomarkers for the prognosis, diagnosis, and even treatment outcome prediction of leukemia and have been shown to play critical roles in controlling leukemia cell activities, such as proliferation, cell death, metastasis, and drug resistance. As a result, lncRNA profiles may have superior predictive and diagnostic potential in leukemia. Accordingly, this review concentrates on the significance of lncRNAs in leukemia progression based on their chromosomal position.
Keywords: Biomarker, cancer, diagnosis, drug resistance, LncRNA, metastasis.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/0122115366265540231201065341	Print ISSN 2211-5366
Publisher Name Bentham Science Publisher	Online ISSN 2211-5374
MicroRNA

The Role of Long Noncoding RNAs in Progression of Leukemia: Based on Chromosomal Location

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Revolutionizing Animal Farming: The Impact of miRNAs on Health and Productivity

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