Title:Antimetastatic Drug, Pharmacologic Challenge and Opportunity
Volume: 20
Issue: 2
Author(s): Da-Yong Lu*Ting-Ren Lu
Affiliation:
- School of Life Sciences, Shanghai University, Shanghai, 200444, PRC, China
Keywords:
Metastatic cascade, pharmacotherapy, cancer plasticity, cancer therapy, animal models, microenvironment, cancer stem cells, herbal medicine.
Abstract:
Cancer is a complex and high-mortality disease in the clinic. Cancer metastasis leads to
most cancer deaths. The therapeutics for cancer metastasis are greatly unsatisfactory now. Despite
different types of antimetastatic agents and drugs have been reported, 90% of patients die in 5 years
after metastatic nodules at secondary sites have been found.
Many pharmacologic challenges and opportunities for current metastasis therapies are presented. To
overcome the dilemma and shortcomings of antimetastatic treatment, medical, chemical, pharmaceutical,
methodological and technical issues are integrated and highlighted. To introduce up-to-date
knowledge and insights into drug targeting and pharmaceutical features and clinical paradigms, relevant
drug design insights are discussed—including different pathological modes, diagnosis advances,
metastatic cascade, tumor plasticity, variety of animal models, therapeutic biomarkers, computational
tools and cancer genomics. Integrated knowledge, systems and therapeutics are focused.
In summary, medicinal comparison, pharmaceutical innovation and clinical strategies should be increasingly
investigated.
