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Abstract
Ankylosing spondylitis (AS) is a complex autoimmune and auto-inflammatory disorder characterized by a gradual onset that can progress to spinal ankylosis over time. This chronic condition primarily affects the sacroiliac joints and the spine, often extending its influence to peripheral joints and extra-articular organs, including the eyes AS is associated with significant disability, along with comorbidities such as uveitis and inflammatory bowel disease. Moreover, individuals with AS face an elevated risk of mortality due to cardiovascular disease (CVD). This paper explores the potential benefits of statins, known for their anti-inflammatory and immunomodulatory effects, in mitigating AS-related cardiovascular risk and their therapeutic effects on disease activity.
Keywords: Ankylosing Spondylitis, inflammatory disease, mortality, cardiovascular disease, immunomodulatory effects, statins.
Current Drug Therapy
Title:Protective Effect of Statin Therapy in Ankylosing Spondylitis
Volume: 19
Author(s): Fataneh Tavasolian, Elham Abdollahi, Robert D. Inman and Amirhossein Sahebkar*
Affiliation:
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords: Ankylosing Spondylitis, inflammatory disease, mortality, cardiovascular disease, immunomodulatory effects, statins.
Abstract: Ankylosing spondylitis (AS) is a complex autoimmune and auto-inflammatory disorder characterized by a gradual onset that can progress to spinal ankylosis over time. This chronic condition primarily affects the sacroiliac joints and the spine, often extending its influence to peripheral joints and extra-articular organs, including the eyes AS is associated with significant disability, along with comorbidities such as uveitis and inflammatory bowel disease. Moreover, individuals with AS face an elevated risk of mortality due to cardiovascular disease (CVD). This paper explores the potential benefits of statins, known for their anti-inflammatory and immunomodulatory effects, in mitigating AS-related cardiovascular risk and their therapeutic effects on disease activity.
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Cite this article as:
Tavasolian Fataneh, Abdollahi Elham, Inman D. Robert and Sahebkar Amirhossein*, Protective Effect of Statin Therapy in Ankylosing Spondylitis, Current Drug Therapy 2024; 19 () . https://dx.doi.org/10.2174/0115748855272102231205111945
DOI https://dx.doi.org/10.2174/0115748855272102231205111945 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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