Title:Future is Brighter: New Potential Paradigm-Shifting Medications and
Regimens for Diabetes and Obesity
Volume: 20
Issue: 8
Author(s): Rami A. Al-Horani*, Kholoud F. Aliter and Hashem F. Aliter
Affiliation:
- Division of Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana
70125, USA
Keywords:
Diabetes, obesity, insulin, semaglutide, teplizumab, orforglipron, retatrutide, tirzepatide, survodutide, cagrisema, ustekinumab, jakinibs.
Abstract: Diabetes is a chronic illness that can become debilitating owing to its microvascular
and macrovascular complications. Its prevalence is increasing and so is its cost. Diabetes, particularly
type 2, appears to have a very close relationship with obesity. While lifestyle modifications,
exercises, and current therapeutics have substantially improved clinical outcomes, the need for
new therapeutics and regimens continue to exist. Several new medications and regimens for diabetes,
obesity, and diabesity are showing promising results in advanced clinical trials. For type 1
diabetes mellitus (T1DM), they include teplizumab, ustekinumab, jakinibs, and cell therapies,
whereas for type 2 diabetes mellitus (T2DM), they include once-weakly insulin, tirzepatide, high
oral dose of semaglutide, orforglipron, retatrutide, CagriSema, and survodutide. Given their structural
and mechanistic diversity as well as their substantial efficacy and safety profiles, these medications
and regimens are paradigm shifting and promise a brighter future. They will likely enable
better disease prevention and management. This review will provide details about each of the
above strategies to keep the scientific community up to date about progress in the fields of diabetes
and obesity.