Title:Unveiling Spanlastics as a Novel Carrier for Drug Delivery: A Review
Volume: 13
Issue: 1
Author(s): Dipanjan Karati, Swarupananda Mukherjee*Bhupendra G. Prajapati*
Affiliation:
- Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata – Group of Institutions, 124, B.L Saha
Road, Kolkata, 700053, India
- Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, 384012, Mahesana, Gujarat, India
Keywords:
Nanotechnology, spanlastics, non-ionic surfactants, targeted drug delivery, biocompatibility, edge activator.
Abstract: Innovative colloidal preparations that can alter the pharmacological properties of drugs
have been made possible by the advancement of nanotechnology. Recent advances in the sciences of
the nanoscale have led to the creation of new methods for treating illnesses. Developments in nanotechnology
may lessen the side effects of medicine by using effective and regulated drug delivery
methods. A promising drug delivery vehicle is spanlastics, an elastic nanovesicle that can transport a
variety of drug compounds. Spanlastics have expanded the growing interest in many types of administrative
pathways. Using this special type of vesicular carriers, medications intended for topical, nasal,
ocular, and trans-ungual treatments are delivered to specific areas. Their elastic and malleable
structure allows them to fit into skin pores, making them ideal for transdermal distribution. Spanlastic
is composed of non-ionic surfactants or combinations of surfactants. Numerous studies have
demonstrated how spanlastics significantly improve, drug bioavailability, therapeutic effectiveness,
and reduce medication toxicity. The several vesicular systems, composition and structure of spanlastics,
benefits of spanlastics over alternative drug delivery methods, and the process of drug penetration
via skin are all summarized in this paper. Additionally, it provides an overview of the many
medications that may be treated using spanlastic vesicles. The primary benefits of these formulations
were associated with their surface properties, as a variety of proteins might be linked to the look. For
instance, procedure assessment and gold nanoparticles were employed as biomarkers for different
biomolecules, which included tumor label detection. Anticipate further advancements in the customization
and combining of spanlastic vesicles with appropriate zeta potential to transport therapeutic
compounds to specific areas for enhanced disease treatment.
